| + |
HOXA10 | down-regulates quantity by repression 
transcriptional regulation
|
MEF2C |
0.288 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254212 |
|
|
Homo sapiens |
JURKAT Cell |
| pmid |
sentence |
| 21261500 |
Overexpression of HOXA9 or HOXA10 in JURKAT cells by lentiviral transduction resulted in decreased expression of MEF2C, indicating repression by these homeodomain proteins. HOXA9/10 inhibits expression of MEF2C via NMYC |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HOXA10 | down-regulates quantity by repression
transcriptional regulation
|
PHGDH |
0.304 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254468 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19778996 |
PHGDH is expressed in both endometrial epithelial and stromal cells. HOXA10 represses endometrial PHGDH expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GATA1 | down-regulates quantity by repression
transcriptional regulation
|
HOXA10 |
0.312 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254470 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17688409 |
Transcription factors GATA-1 and Fli-1 regulate human HOXA10 expression in megakaryocytic cells. Mutation of the GATA-1 and the Ets-1 motifs amplified the expression of HOXA10 in HEL and K562 cells, confirming the importance of these cis-acting elements in regulating HOXA10 expression in megakaryocytic cells. Chromatin immunoprecipitation (ChIP) and chloramphenicol acetyl transferase (CAT) assays confirm that HOXA11 binds to the putative binding site, resulting in repression of HOXA10 expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HOXA10 | up-regulates quantity by expression 
transcriptional regulation
|
MYCN |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254215 |
|
|
Homo sapiens |
JURKAT Cell |
| pmid |
sentence |
| 21261500 |
HOXA9/HOXA10 activated expression of NMYC which in turn mediated MEF2C repression, indicating an indirect mode of regulation via NMYC interactor (NMI) and STAT5. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PTPN11 | up-regulates 
dephosphorylation
|
HOXA10 |
0.38 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-182475 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19022774 |
We also identified hoxa10 as a substrate for shp2 in undifferentiated myeloid cells, an effect that diminished during myelopoiesis. However, a constitutively active form of shp2 dephosphorylated hoxa10 throughout ex vivo myelopoiesis and sustained repression of hoxa10 target genes involved in phagocyte effector functions. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HOXA10 | up-regulates quantity by expression
transcriptional regulation
|
EMX2 |
0.325 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254465 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15494461 |
EMSA demonstrated HOXA10-Pbx2 binding as a heterodimer to an enhancer of the EMX2 gene, a known target of HOXA10 regulation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SETBP1 | up-regulates quantity by expression
transcriptional regulation
|
HOXA10 |
0.352 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-197318 |
|
|
Homo sapiens |
Leukemia Cell |
| pmid |
sentence |
| 22566606 |
Setbp1 activates hoxa9 and hoxa10 expression in myeloid progenitors |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PHF1 | down-regulates quantity by repression 
transcriptional regulation
|
HOXA10 |
0.289 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260071 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20565746 |
These data support the proposed regulatory impact of particular PRC2-proteins in expression of HOXA9 and HOXA10 in NK/T-cells. In mammalian cells knockdown of PRC2 components EZH2 or PHF1 led to upregulated HOXA gene expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HOXA10 | down-regulates quantity by repression
transcriptional regulation
|
IGFBP1 |
0.421 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254467 |
|
|
Homo sapiens |
Endometrial Stromal Cell |
| pmid |
sentence |
| 17350963 |
The functional role of HOXA10 in IGFBP1 expression was further explored using human endometrial stromal cells (HSC). Overexpression of HOXA10 in HSC resulted in a decrease of IGFBP1 mRNA, whereas silencing HOXA10 caused an increase of IGFBP1 mRNA, even in the presence of H + dbcAMP. These data demonstrate that HOXA10 negatively influences IGFBP1 expression in decidualizing cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
KDM6A | up-regulates quantity by expression
transcriptional regulation
|
HOXA10 |
0.271 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260020 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24561908 |
Evidence for direct involvement of UTX in regulation of HOX gene activity was demonstrated through UTX knockdown experiments in HEK293T cells in which loss of UTX induced transcriptional repression of HOXA and HOXC clusters. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HOXA11 | down-regulates quantity by repression
transcriptional regulation
|
HOXA10 |
0.298 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254469 |
|
|
Homo sapiens |
Megakaryocyte Cell Line |
| pmid |
sentence |
| 17688409 |
Chromatin immunoprecipitation (ChIP) and chloramphenicol acetyl transferase (CAT) assays confirm that HOXA11 binds to the putative binding site, resulting in repression of HOXA10 expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
EZH2 | down-regulates quantity by repression
transcriptional regulation
|
HOXA10 |
0.449 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260070 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20565746 |
These data support the proposed regulatory impact of particular PRC2-proteins in expression of HOXA9 and HOXA10 in NK/T-cells. In mammalian cells knockdown of PRC2 components EZH2 or PHF1 led to upregulated HOXA gene expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FLI1 | down-regulates quantity by repression
transcriptional regulation
|
HOXA10 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254471 |
|
|
Homo sapiens |
Megakaryocyte Cell Line |
| pmid |
sentence |
| 17688409 |
Transcription factors GATA-1 and Fli-1 regulate human HOXA10 expression in megakaryocytic cells. Mutation of the GATA-1 and the Ets-1 motifs amplified the expression of HOXA10 in HEL and K562 cells, confirming the importance of these cis-acting elements in regulating HOXA10 expression in megakaryocytic cells. Chromatin immunoprecipitation (ChIP) and chloramphenicol acetyl transferase (CAT) assays confirm that HOXA11 binds to the putative binding site, resulting in repression of HOXA10 expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HOXA10 | up-regulates quantity by expression
transcriptional regulation
|
MYLK |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261643 |
|
|
Rattus norvegicus |
A10 Cell |
| pmid |
sentence |
| 15886193 |
Results from these experiments demonstrated that in 10T1/2 cells Hoxa10-1 increased the activity of the telokin promoter 3-fold without affecting the activity of the other promoters analyzed (Fig. 2A). Similar results were also observed in A10 SMC (data not shown). In contrast, Hoxb8 significantly repressed the activity of the telokin, smooth muscle α-actin, and SM22α promoters by 70, 50, and 70%, respectively |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
3.0
HOXA10
- 
- 