| + |
CSNK2A1 | down-regulates activity 
phosphorylation
|
HOXB7 |
0.351 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250896 |
Ser133 |
IYPWMRSsGTDRKRG |
Mus musculus |
32D Cell |
| pmid |
sentence |
| 11290787 |
Thus, we concluded that CKII can phosphorylate HOXB7 in vitro and that this phosphorylation occurs at both of the CKII target sites, S133 and T204. | Wild-type HOXB7 inhibited the differentiation of 32D cells, whereas mutations in the Pbx-binding pentapeptide motif or the DNA-binding homeodomain, as well as internal deletions of the N-terminal unique region, blocked this effect. Interestingly, mutations eliminating two target sites for casein kinase II, the glutamate-rich C terminus, or the first 14 amino acids of HOXB7, led to enhanced 32D differentiation. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250897 |
Thr204 |
KTAGPGTtGQDRAEA |
Mus musculus |
32D Cell |
| pmid |
sentence |
| 11290787 |
Thus, we concluded that CKII can phosphorylate HOXB7 in vitro and that this phosphorylation occurs at both of the CKII target sites, S133 and T204. | Wild-type HOXB7 inhibited the differentiation of 32D cells, whereas mutations in the Pbx-binding pentapeptide motif or the DNA-binding homeodomain, as well as internal deletions of the N-terminal unique region, blocked this effect. Interestingly, mutations eliminating two target sites for casein kinase II, the glutamate-rich C terminus, or the first 14 amino acids of HOXB7, led to enhanced 32D differentiation. |
|
| Publications: |
2 |
Organism: |
Mus Musculus |
| + |
HOXB7 | up-regulates quantity by expression 
transcriptional regulation
|
FGF2 |
0.404 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261639 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 8756643 |
Band shift and cotransfection experiments showed that HOXB7 directly transactivates the hFGF gene through one out of five putative homeodomain binding sites present in its promoter. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HOXB7 | up-regulates activity
binding
|
PRKDC |
0.339 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-226063 |
|
|
Homo sapiens |
SK-BR-3 Cell |
| pmid |
sentence |
| 17308091 |
Ku70 and Ku80 associated with HOXB7 in vivo. Ku70/Ku80 heterodimer formation is a prerequisite for HOXB7 binding. interaction between Ku70/80 and HOXB7 may affect the catalytic activity of DNA-PK. HOXB7 stimulates DNA-PK activity |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
HOXB7
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