Summary

Name FGF2
Full Name Fibroblast growth factor 2
Synonyms FGF-2, Basic fibroblast growth factor, bFGF, Heparin-binding growth factor 2, HBGF-2 | FGFB
Primary ID P09038
Links - -
Type protein
Relations 24
Function Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4 (PubMed:8663044). Also acts as an integrin ligand which is required for FGF2 signaling (PubMed:28302677). Binds to integrin ITGAV:ITGB3 (PubMed:28302677). Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration (PubMed:8663044, PubMed:28302677). Functions as a potent mitogen in vitro (PubMed:1721615, PubMed:3964259, PubMed:3732516). Can induce angiogenesis (PubMed:23469107, PubMed:28302677). Mediates phosphorylation of ERK1/2 and thereby promotes retinal lens fiber differentiation (PubMed:29501879).

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Relations

Regulator Mechanism target score
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation HBA1 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation FGF2 0.459
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation ENPP1 0.261
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation ALPL 0.389
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation ANKH 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png Gbeta 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png Angiogenesis 0.7
Publications: 1
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation TGFB1 0.465
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation MMP13 0.438
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png MAPK8 0.392
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation FGF2 0.412
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding FGFR2 0.894
Publications: 2 Organism: Homo Sapiens, Rattus Norvegicus
Tissue: Prostate Gland Cancer Cell
+ up-regulates img/indirect-activation.png MAPK1 0.599
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png MAPK3 0.587
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png MAPK14 0.406
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png ERK1/2 0.599
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding FGFR3 0.811
Publications: 2 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation HBB 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding FGFR4 0.81
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png RUNX2 0.459
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation BMP2 0.493
Publications: 1 Organism: Homo Sapiens