Summary

Name FURIN
Full Name Furin
Synonyms Dibasic-processing enzyme, Paired basic amino acid residue-cleaving enzyme, PACE | FUR, PACE, PCSK3
Primary ID P09958
Links - -
Type protein
Relations 5
Pathways SARS-CoV ATTACHMENT AND ENTRY
Function Ubiquitous endoprotease within constitutive secretory pathways capable of cleavage at the RX(K/R)R consensus motif (PubMed:11799113, PubMed:1629222, PubMed:1713771, PubMed:2251280, PubMed:24666235, PubMed:25974265, PubMed:7592877, PubMed:7690548, PubMed:9130696). Mediates processing of TGFB1, an essential step in TGF-beta-1 activation (PubMed:7737999). Converts through proteolytic cleavage the non-functional Brain natriuretic factor prohormone into its active hormone BNP(1-32) (PubMed:20489134, PubMed:21763278).

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Relations

Regulator Mechanism target score ℹ
+ FURINup-regulates img/direct-activation.png binding NOTCH1 0.653
Publications: 1 Organism: Homo Sapiens
+ FURINup-regulates activity img/direct-activation.png cleavage INSR 0.287
Publications: 1 Organism: Homo Sapiens
+ FURINup-regulates activity img/direct-activation.png cleavage VWF 0.495
Publications: 1
+ FURINup-regulates activity img/direct-activation.png cleavage S 0.2
Publications: 2 Organism: Homo Sapiens
Pathways:SARS-CoV ATTACHMENT AND ENTRY