| + |
MASP1 | up-regulates activity 
cleavage
|
C4B |
0.663 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263423 |
Arg679 |
EKTTRKKrNVNFQKA |
in vitro |
|
| pmid |
sentence |
| 9087411 |
The classical complement activation pathway, like the MELinitiated pathway, involves the generation of a C3-converting complex, C4b2b, through enzymatic activation of C4 and C2. In the C1 complex (C1qr2s2), this specific protease activity is exhibited by C1s after activation of this enzyme by C1r. When C4 is activated, its reactive thiol ester is exposed and C4b binds covalently to nearby amino or hydroxyl groups. The C4-activating abilities of MASP-1 and MASP-2 were compared.|Activation of C4 by Ct sand MASP-2 on western blots. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263426 |
Arg756 |
KGQAGLQrALEILQE |
in vitro |
|
| pmid |
sentence |
| 9087411 |
The classical complement activation pathway, like the MELinitiated pathway, involves the generation of a C3-converting complex, C4b2b, through enzymatic activation of C4 and C2. In the C1 complex (C1qr2s2), this specific protease activity is exhibited by C1s after activation of this enzyme by C1r. When C4 is activated, its reactive thiol ester is exposed and C4b binds covalently to nearby amino or hydroxyl groups. The C4-activating abilities of MASP-1 and MASP-2 were compared.|Activation of C4 by Ct sand MASP-2 on western blots. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263429 |
Gly1446 |
TPLQLFEgRRNRRRR |
in vitro |
|
| pmid |
sentence |
| 9087411 |
The classical complement activation pathway, like the MELinitiated pathway, involves the generation of a C3-converting complex, C4b2b, through enzymatic activation of C4 and C2. In the C1 complex (C1qr2s2), this specific protease activity is exhibited by C1s after activation of this enzyme by C1r. When C4 is activated, its reactive thiol ester is exposed and C4b binds covalently to nearby amino or hydroxyl groups. The C4-activating abilities of MASP-1 and MASP-2 were compared.|Activation of C4 by Ct sand MASP-2 on western blots. |
|
| Publications: |
3 |
Organism: |
In Vitro |
| + |
MASP2 | up-regulates activity
cleavage
|
C4B |
0.793 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263422 |
Arg679 |
EKTTRKKrNVNFQKA |
in vitro |
|
| pmid |
sentence |
| 17204478 |
MASP-2 cleaves C4 releasing C4a and generating C4b, which attaches covalently to the pathogen surface upon exposure of its reactive thioester. C2 binds to C4b and is also cleaved by MASP-2 to form the C3 convertase (C4b2a). |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263425 |
Arg756 |
KGQAGLQrALEILQE |
in vitro |
|
| pmid |
sentence |
| 17204478 |
MASP-2 cleaves C4 releasing C4a and generating C4b, which attaches covalently to the pathogen surface upon exposure of its reactive thioester. C2 binds to C4b and is also cleaved by MASP-2 to form the C3 convertase (C4b2a). |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263428 |
Gly1446 |
TPLQLFEgRRNRRRR |
in vitro |
|
| pmid |
sentence |
| 17204478 |
MASP-2 cleaves C4 releasing C4a and generating C4b, which attaches covalently to the pathogen surface upon exposure of its reactive thioester. C2 binds to C4b and is also cleaved by MASP-2 to form the C3 convertase (C4b2a). |
|
| Publications: |
3 |
Organism: |
In Vitro |
| + |
Complement C1 complex | up-regulates activity
cleavage
|
C4B |
0.63 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263424 |
Arg679 |
EKTTRKKrNVNFQKA |
in vitro |
|
| pmid |
sentence |
| 9087411 |
The classical complement activation pathway, like the MELinitiated pathway, involves the generation of a C3-converting complex, C4b2b, through enzymatic activation of C4 and C2. In the C1 complex (C1qr2s2), this specific protease activity is exhibited by C1s after activation of this enzyme by C1r. When C4 is activated, its reactive thiol ester is exposed and C4b binds covalently to nearby amino or hydroxyl groups. The C4-activating abilities of MASP-1 and MASP-2 were compared.|Activation of C4 by Ct sand MASP-2 on western blots. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263427 |
Arg756 |
KGQAGLQrALEILQE |
in vitro |
|
| pmid |
sentence |
| 9087411 |
The classical complement activation pathway, like the MELinitiated pathway, involves the generation of a C3-converting complex, C4b2b, through enzymatic activation of C4 and C2. In the C1 complex (C1qr2s2), this specific protease activity is exhibited by C1s after activation of this enzyme by C1r. When C4 is activated, its reactive thiol ester is exposed and C4b binds covalently to nearby amino or hydroxyl groups. The C4-activating abilities of MASP-1 and MASP-2 were compared.|Activation of C4 by Ct sand MASP-2 on western blots. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263430 |
Gly1446 |
TPLQLFEgRRNRRRR |
in vitro |
|
| pmid |
sentence |
| 9087411 |
The classical complement activation pathway, like the MELinitiated pathway, involves the generation of a C3-converting complex, C4b2b, through enzymatic activation of C4 and C2. In the C1 complex (C1qr2s2), this specific protease activity is exhibited by C1s after activation of this enzyme by C1r. When C4 is activated, its reactive thiol ester is exposed and C4b binds covalently to nearby amino or hydroxyl groups. The C4-activating abilities of MASP-1 and MASP-2 were compared.|Activation of C4 by Ct sand MASP-2 on western blots. |
|
| Publications: |
3 |
Organism: |
In Vitro |
| + |
CSMD1 | down-regulates quantity 
binding
|
C4B |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265149 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 28345259 |
CUB and sushi multiple domains 1 (CSMD1) is a relatively poorly studied large transmembrane protein of 390 kDa composed of 14 N-terminal CUB domains interspersed with complement control protein (CCP) domains followed by 15 consecutive CCP domains. The active domains of CSMD1 were then identified in CCP17-21, which were shown to interact with C4b and C3b and present these complement proteins for degradation by factor |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
C4B | form complex 
binding
|
C3 convertase complex |
0.655 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263398 |
|
|
in vitro |
|
| pmid |
sentence |
| 17204478 |
However, following cleavage of C4, C2 binds tightly to C4b to form the C4b2 complex |
|
| Publications: |
1 |
Organism: |
In Vitro |
3.0
C4B
- 
- 