| + |
CSMD1 | down-regulates quantity 
binding
|
C3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265148 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 28345259 |
CUB and sushi multiple domains 1 (CSMD1) is a relatively poorly studied large transmembrane protein of 390 kDa composed of 14 N-terminal CUB domains interspersed with complement control protein (CCP) domains followed by 15 consecutive CCP domains. The active domains of CSMD1 were then identified in CCP17-21, which were shown to interact with C4b and C3b and present these complement proteins for degradation by factor |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CSMD1 | down-regulates quantity
binding
|
C4B |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265149 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 28345259 |
CUB and sushi multiple domains 1 (CSMD1) is a relatively poorly studied large transmembrane protein of 390 kDa composed of 14 N-terminal CUB domains interspersed with complement control protein (CCP) domains followed by 15 consecutive CCP domains. The active domains of CSMD1 were then identified in CCP17-21, which were shown to interact with C4b and C3b and present these complement proteins for degradation by factor |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CSMD1 | up-regulates activity 
binding
|
SMAD3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265151 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22538441 |
CSMD1 co-immunoprecipitated with SMAD3, confirming our results that CSMD1 interacts with Smad3 in A375 cells. CSMD1 interacts with Smad3 and induces phosphorylation (p-Smad3). Phosphorylated Smad3 promotes Smad2 phosphorylation and Smad2/3/4 complex formation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CSMD1 | down-regulates 
|
Angiogenesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265150 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22538441 |
CSMD1 inhibits tumor growth, angiogenesis, and survival rate in vivo |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
CSMD1
- 
- 