+ |
Host translation inhibitor nsp1 | down-regulates activity
|
JUN |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-262505 |
|
|
Homo sapiens |
HEK-293 Cell |
pmid |
sentence |
17715225 |
SARS-CoV nsp1 inhibits c-Jun expression and phosphorylation. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
Pathways: | SARS-CoV CYTOKINE STORM |
+ |
Host translation inhibitor nsp1 | down-regulates activity
|
STAT1 |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-262502 |
|
|
Homo sapiens |
HEK-293 Cell |
pmid |
sentence |
17715225 |
We mapped a strong inhibitory activity to SARS-CoV nonstructural protein 1 (nsp1) and show that expression of nsp1 significantly inhibited the activation of all three virus-dependent signaling pathways. We show that expression of nsp1 significantly inhibited IFN-dependent signaling by decreasing the phosphorylation levels of STAT1 while having little effect on those of STAT2, JAK1, and TYK2. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
Pathways: | SARS-CoV CYTOKINE STORM |
+ |
Host translation inhibitor nsp1 | down-regulates activity
|
IRF7 |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-262504 |
|
|
Homo sapiens |
|
pmid |
sentence |
17715225 |
SARS-CoV nsp1 inhibits virus-dependent activation of IRF3 and IRF7. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
Pathways: | SARS-CoV CYTOKINE STORM |
+ |
Host translation inhibitor nsp1 | down-regulates activity
|
IRF3 |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-262503 |
|
|
Homo sapiens |
|
pmid |
sentence |
17715225 |
SARS-CoV nsp1 inhibits virus-dependent activation of IRF3 and IRF7. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
Pathways: | SARS-CoV ATTACHMENT AND ENTRY, SARS-CoV INFLAMMATORY RESPONSE, SARS-CoV INNATE RESPONSE TO dsRNA, SARS-CoV STRESS GRANULES |