Summary

Name IRF7
Full Name Interferon regulatory factor 7
Synonyms IRF-7
Primary ID Q92985
Links - -
Type protein
Relations 13
Pathways EBV infection, Innate Immune Response, SARS-CoV CYTOKINE STORM
Function Key transcriptional regulator of type I interferon (IFN)-dependent immune responses and plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters (PubMed:17574024, PubMed:32972995). Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction via both the virus-activated, MyD88-independent pathway and the TLR-activated, MyD88-dependent pathway. Induces transcription of ubiquitin hydrolase USP25 mRNA in response to lipopolysaccharide (LPS) or viral infection in a type I IFN-dependent manner (By similarity). Required during both the early and late phases of the IFN gene induction but is more critical for the late than for the early phase. Exists in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, becomes phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization where along with other coactivators it can activate transcription of the type I IFN and ISG genes. Can also play a role in regulating adaptive immune responses by inducing PSMB9/LMP2 expression, either directly or through induction of IRF1. Binds to the Q promoter (Qp) of EBV nuclear antigen 1 a (EBNA1) and may play a role in the regulation of EBV latency. Can activate distinct gene expression programs in macrophages and regulate the anti-tumor properties of primary macrophages (By similarity) (PubMed:11073981, PubMed:12374802, PubMed:15361868, PubMed:17404045).

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▶Modifications Tables

Relations

Regulator Mechanism target score ℹ
+ UBE2Idown-regulates activity img/direct_inhibition.png sumoylation IRF7 0.292
Publications: 1 Organism: Homo Sapiens
Pathways:EBV infection
+ IKBKEup-regulates img/direct-activation.png phosphorylation IRF7 0.675
Publications: 2 Organism: Homo Sapiens
Pathways:Innate Immune Response
+ LF2down-regulates activity img/direct_inhibition.png binding IRF7 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:EBV infection
+ IRF7up-regulates quantity by expression img/indirect-activation.png transcriptional regulation IFNA1 0.56
Publications: 1 Organism: Homo Sapiens
Pathways:SARS-CoV CYTOKINE STORM
+ BZLF1down-regulates activity img/direct_inhibition.png binding IRF7 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:EBV infection
+ IRF7up-regulates quantity by expression img/indirect-activation.png transcriptional regulation Interferon-type-I 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:EBV infection, Innate Immune Response
+ CHUKup-regulates img/direct-activation.png phosphorylation IRF7 0.68
Publications: 1 Organism: Homo Sapiens
+ STAT1up-regulates quantity by expression img/indirect-activation.png transcriptional regulation IRF7 0.497
Publications: 1 Organism: Homo Sapiens
Pathways:EBV infection, SARS-CoV CYTOKINE STORM
+ TRIM59down-regulates activity img/indirect_inhibition.png IRF7 0.261
Publications: 1 Organism: Homo Sapiens
+ Host translation inhibitor nsp1down-regulates activity img/indirect_inhibition.png IRF7 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:SARS-CoV CYTOKINE STORM
+ BRLF1down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation IRF7 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:EBV infection
+ LMP1down-regulates activity img/direct_inhibition.png sumoylation IRF7 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:EBV infection