Summary

Name 6
Full Name ORF6 protein
Synonyms ORF6, Accessory protein 6, Non-structural protein 6, ns6, Protein X3 |
Primary ID P0DTC6
Links - -
Type protein
Relations 2
Pathways SARS-CoV INFLAMMATORY RESPONSE, SARS-CoV INNATE RESPONSE TO dsRNA, SARS-CoV STRESS GRANULES
Function Disrupts cell nuclear import complex formation by tethering karyopherin alpha 2 and karyopherin beta 1 to the membrane. Retention of import factors at the ER/Golgi membrane leads to a loss of transport into the nucleus. Thereby prevents STAT1 nuclear translocation in response to interferon signaling, thus blocking the expression of interferon stimulated genes (ISGs) that display multiple antiviral activities.

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Relations

Regulator Mechanism target score
+ down-regulates activity img/indirect_inhibition.png DDX58 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:SARS-CoV INNATE RESPONSE TO dsRNA, SARS-CoV STRESS GRANULES
+ down-regulates activity img/direct_inhibition.png binding KPNA2 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:SARS-CoV INFLAMMATORY RESPONSE