Relation Results

Summary

Name	DDX58 View Modifications
Full Name	Antiviral innate immune response receptor RIG-I
Synonyms	DEAD box protein 58, RIG-I-like receptor 1, RLR-1, Retinoic acid-inducible gene 1 protein, RIG-1, Retinoic acid-inducible gene I protein, RIG-I
Primary ID	O95786
Links	- -
Type	protein
Relations	20
Pathways	COVID-19 Causal Network, Innate Immune Response, SARS-CoV INNATE RESPONSE TO dsRNA, SARS-CoV STRESS GRANULES
Function	Innate immune receptor that senses cytoplasmic viral nucleic acids and activates a downstream signaling cascade leading to the production of type I interferons and proinflammatory cytokines. Forms a ribonucleoprotein complex with viral RNAs on which it homooligomerizes to form filaments. The homooligomerization allows the recruitment of RNF135 an E3 ubiquitin-protein ligase that activates and amplifies the RIG-I-mediated antiviral signaling in an RNA length-dependent manner through ubiquitination-dependent and -independent mechanisms (PubMed:28469175, PubMed:31006531). Upon activation, associates with mitochondria antiviral signaling protein (MAVS/IPS1) that activates the IKK-related kinases TBK1 and IKBKE which in turn phosphorylate the interferon regulatory factors IRF3 and IRF7, activating transcription of antiviral immunological genes including the IFN-alpha and IFN-beta interferons (PubMed:28469175, PubMed:31006531). Ligands include 5'-triphosphorylated ssRNAs and dsRNAs but also short dsRNAs (<1 kb in length). In addition to the 5'-triphosphate moiety, blunt-end base pairing at the 5'-end of the RNA is very essential. Overhangs at the non-triphosphorylated end of the dsRNA RNA have no major impact on its activity. A 3'overhang at the 5'triphosphate end decreases and any 5'overhang at the 5' triphosphate end abolishes its activity. Detects both positive and negative strand RNA viruses including members of the families Paramyxoviridae

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▶Modifications Tables

Relations

Regulator

Mechanism

target

score ℹ

up-regulates activity img/direct-activation.png

img/direct-activation.png

ubiquitination

0.2

Publications:

1

down-regulates quantity by destabilization img/direct_inhibition.png

img/direct_inhibition.png

ubiquitination

0.2

Publications:

1

Organism:

Homo Sapiens

up-regulates activity img/direct-activation.png

img/direct-activation.png

ubiquitination

0.756

Publications:

2

Organism:

Homo Sapiens

up-regulates activity img/direct-activation.png

img/direct-activation.png

dephosphorylation

0.2

Publications:

1

Organism:

Homo Sapiens

Pathways:

COVID-19 Causal Network

up-regulates activity img/direct-activation.png

img/direct-activation.png

dephosphorylation

0.2

Publications:

1

Organism:

Homo Sapiens

down-regulates img/direct_inhibition.png

img/direct_inhibition.png

phosphorylation

0.2

Publications:

3

Organism:

Homo Sapiens

Pathways:

COVID-19 Causal Network, SARS-CoV STRESS GRANULES

down-regulates activity img/direct_inhibition.png

img/direct_inhibition.png

phosphorylation

0.337

Publications:

1

Organism:

Homo Sapiens

down-regulates activity img/direct_inhibition.png

img/direct_inhibition.png

phosphorylation

0.2

Publications:

1

Organism:

Homo Sapiens

down-regulates quantity by destabilization img/direct_inhibition.png

img/direct_inhibition.png

polyubiquitination

0.658

Publications:

1

Organism:

Homo Sapiens

up-regulates activity img/direct-activation.png

img/direct-activation.png

binding

0.935

Publications:

1

Organism:

Homo Sapiens

Pathways:

COVID-19 Causal Network, Innate Immune Response, SARS-CoV INNATE RESPONSE TO dsRNA, SARS-CoV STRESS GRANULES

down-regulates activity img/direct_inhibition.png

img/direct_inhibition.png

binding

0.4

Publications:

1

Organism:

Homo Sapiens

up-regulates img/direct-activation.png

img/direct-activation.png

0.7

Publications:

1

Organism:

Homo Sapiens

Pathways:

COVID-19 Causal Network, Innate Immune Response, SARS-CoV INNATE RESPONSE TO dsRNA, SARS-CoV STRESS GRANULES

up-regulates quantity img/indirect-activation.png

img/indirect-activation.png

0.346

Publications:

1

Organism:

Homo Sapiens

Pathways:

COVID-19 Causal Network, Innate Immune Response, SARS-CoV STRESS GRANULES

up-regulates activity img/direct-activation.png

img/direct-activation.png

polyubiquitination

0.796

Publications:

1

Organism:

Homo Sapiens

down-regulates activity img/indirect_inhibition.png

img/indirect_inhibition.png

0.2

Publications:

1

Organism:

Homo Sapiens

Pathways:

COVID-19 Causal Network, SARS-CoV INNATE RESPONSE TO dsRNA, SARS-CoV STRESS GRANULES

down-regulates activity img/indirect_inhibition.png

img/indirect_inhibition.png

0.2

Publications:

1

Organism:

Homo Sapiens

Pathways:

SARS-CoV INNATE RESPONSE TO dsRNA, SARS-CoV STRESS GRANULES

down-regulates activity img/direct_inhibition.png

img/direct_inhibition.png

binding

0.346

Publications:

1

Organism:

Homo Sapiens

Pathways:

COVID-19 Causal Network, Innate Immune Response, SARS-CoV STRESS GRANULES