Summary

Name DDX58
Full Name Antiviral innate immune response receptor RIG-I
Synonyms DEAD box protein 58, RIG-I-like receptor 1, RLR-1, Retinoic acid-inducible gene 1 protein, RIG-1, Retinoic acid-inducible gene I protein, RIG-I
Primary ID O95786
Links - -
Type protein
Relations 18
Pathways COVID-19 Causal Network, Innate Immune Response, SARS-CoV INNATE RESPONSE TO dsRNA, SARS-CoV STRESS GRANULES
Function Innate immune receptor that senses cytoplasmic viral nucleic acids and activates a downstream signaling cascade leading to the production of type I interferons and proinflammatory cytokines. Forms a ribonucleoprotein complex with viral RNAs on which it homooligomerizes to form filaments. The homooligomerization allows the recruitment of RNF135 an E3 ubiquitin-protein ligase that activates and amplifies the RIG-I-mediated antiviral signaling in an RNA length-dependent manner through ubiquitination-dependent and -independent mechanisms (PubMed:28469175, PubMed:31006531). Upon activation, associates with mitochondria antiviral signaling protein (MAVS/IPS1) that activates the IKK-related kinases TBK1 and IKBKE which in turn phosphorylate the interferon regulatory factors IRF3 and IRF7, activating transcription of antiviral immunological genes including the IFN-alpha and IFN-beta interferons (PubMed:28469175, PubMed:31006531). Ligands include 5'-triphosphorylated ssRNAs and dsRNAs but also short dsRNAs (<1 kb in length). In addition to the 5'-triphosphate moiety, blunt-end base pairing at the 5'-end of the RNA is very essential. Overhangs at the non-triphosphorylated end of the dsRNA RNA have no major impact on its activity. A 3'overhang at the 5'triphosphate end decreases and any 5'overhang at the 5' triphosphate end abolishes its activity. Detects both positive and negative strand RNA viruses including members of the families Paramyxoviridae

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png ubiquitination DDX58 0.2
Publications: 1
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination DDX58 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png ubiquitination DDX58 0.748
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png dephosphorylation DDX58 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network
+ up-regulates activity img/direct-activation.png dephosphorylation DDX58 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation DDX58 0.2
Publications: 3 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, SARS-CoV STRESS GRANULES
+ down-regulates quantity by destabilization img/direct_inhibition.png polyubiquitination DDX58 0.652
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png DDX58 0.7
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, Innate Immune Response, SARS-CoV INNATE RESPONSE TO dsRNA, SARS-CoV STRESS GRANULES
+ up-regulates quantity img/indirect-activation.png DDX58 0.339
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, Innate Immune Response, SARS-CoV STRESS GRANULES
+ down-regulates activity img/indirect_inhibition.png DDX58 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:SARS-CoV INNATE RESPONSE TO dsRNA, SARS-CoV STRESS GRANULES
+ down-regulates activity img/indirect_inhibition.png DDX58 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, SARS-CoV INNATE RESPONSE TO dsRNA, SARS-CoV STRESS GRANULES
+ down-regulates activity img/direct_inhibition.png binding DDX58 0.401
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding DDX58 0.339
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, Innate Immune Response, SARS-CoV STRESS GRANULES
+ up-regulates activity img/direct-activation.png polyubiquitination DDX58 0.788
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding MAVS 0.934
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, Innate Immune Response, SARS-CoV INNATE RESPONSE TO dsRNA, SARS-CoV STRESS GRANULES