Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-262658 |
Ser27 |
VKKKARKsAGAAKRK |
Homo sapiens |
MCF-7 Cell |
pmid |
sentence |
21511733 |
we showed previously that phosphorylation of S27 in human histone H1.4 (H1.4S27-P), prevents binding of heterochromatin protein 1 (HP1) family members (officially known as chromobox protein homologs) to the neighboring dimethylated K26. Here, we present the first functional characterization of H1.4S27-P in vivo and in vitro. We show that H1.4S27 phosphorylation is cell-cycle-regulated and its levels peak on metaphase chromosomes. We identify further Aurora B as the kinase phosphorylating H1.4S27. |
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