Summary

Name CDK4
Full Name Cyclin-dependent kinase 4
Synonyms Cell division protein kinase 4, PSK-J3
Primary ID P11802
Links - -
Type protein
Relations 73
Pathways Pancreatic ductal adenocarcinoma (PDA)
Inhibitors palbociclib; R547; N-[6,6-dimethyl-5-[(1-methyl-4-piperidinyl)-oxomethyl]-1,4-dihydropyrrolo[3,4-c]pyrazol-3-yl]-3-methylbutanamide; 4-(2,6-dichlorobenzamido)-N-(piperidin-4-yl)-pyrazole-3-carboxamide; alvocidib; alvocidib hydrochloride
Function Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity. Component of the ternary complex, cyclin D/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.

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Relations


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Regulator Mechanism target score ℹ
+ CDK4down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation GATA4 0.353
Publications: 1 Organism: Homo Sapiens
+ CDK4up-regulates activity img/direct-activation.png phosphorylation GATA4 0.353
Publications: 1 Organism: Homo Sapiens
+ CDK4