| + |
CDK4 | down-regulates quantity by destabilization 
phosphorylation
|
GATA4 |
0.365 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276317 |
Ser105 |
AYTPPPVsPRFSFPG |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 21447557 |
Finally, CDK4 phosphorylated GATA4 directly, which promoted the degradation of GATA4 in cultured cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PKA | up-regulates activity 
phosphorylation
|
GATA4 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276043 |
Ser262 |
IKPQRRLsASRRVGL |
Homo sapiens |
MCF-7 Cell |
| pmid |
sentence |
| 16109788 |
PKA-mediated phosphorylation increases the interaction between GATA3 and LRH-1 and the requirement for PKA in aromatase PII promoter stimulation involves at least three specific amino acid residues: GATA3 Ser308, GATA4 Ser261, and LRH-1 Ser469. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GATA4 | down-regulates quantity by repression
transcriptional regulation
|
TDO2 |
0.255 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268994 |
|
|
|
Hepatocyte |
| pmid |
sentence |
| 19003156 |
GATA4 inhibits expression of the tryptophan oxygenase gene by binding to the TATA box in fetal hepatocytes. |
|
| Publications: |
1 |
| + |
GATA4 | up-regulates quantity by expression 
transcriptional regulation
|
HAMP |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254196 |
|
|
Homo sapiens |
Hep-G2 Cell |
| pmid |
sentence |
| 21609320 |
Co-transfection of a GATA-4 expression vector with a hepcidin promoter reporter construct enhanced hepcidin promoter transcriptional activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
POU5F1 | down-regulates quantity by repression 
transcriptional regulation
|
GATA4 |
0.513 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253161 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22795133 |
Knockdown of Oct4 or Nanog induced an increase in the expression of Pax6, Gata4, Gata6, Sox17, and FoxA2 in E, H, and p21KD MSCs ( Figure 3F and Figure S2D) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NANOG | down-regulates quantity by repression
transcriptional regulation
|
GATA4 |
0.455 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254626 |
|
|
Homo sapiens |
Embryonic Stem Cell, Embryonic Carcinoma Cell |
| pmid |
sentence |
| 15983365 |
Transfection of NANOG-specific small interfering RNAs reduced levels of NANOG transcript and protein and induced activation of the extraembryonic endoderm-associated genes GATA4, GATA6, LAMININ B1, and AFP as well as upregulation of trophectoderm-associated genes CDX2, GATA2, hCG-alpha, and hCG-beta. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253162 |
|
|
Homo sapiens |
Mesenchymal Stem Cell |
| pmid |
sentence |
| 22795133 |
Knockdown of Oct4 or Nanog induced an increase in the expression of Pax6, Gata4, Gata6, Sox17, and FoxA2 in E, H, and p21KD MSCs ( Figure 3F and Figure S2D) |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
GATA4 | up-regulates quantity by expression
transcriptional regulation
|
CTNNA3 |
0.253 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265490 |
|
|
Homo sapiens |
Cardiac Muscle Fiber |
| pmid |
sentence |
| 21598020 |
GATA-4 and MEF2C are known to bind to the GATA box 2 in the major promoter of CTNNA3 and this element is essential in directly regulating expression of CTNNA3 in cardiac muscle cells. The co-transfection of GATA-4 with MEF2C leads to a synergistic activation of the CTNNA3 promoter |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GATA4 | up-regulates
|
Differentiation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265480 |
|
|
Homo sapiens |
Embryonic Stem Cell |
| pmid |
sentence |
| 32376282 |
HYDIN promotes expression of Gata4 in cardiomyocyte differentiation. HYDIN functions as a positive regulator of human cardiomyocyte differentiation and promotes expression of cardiac contractile genes in hESC cells. This is mediated through GATA4, a critical transcription factor in heart development. Cardiac-specific Hydin knockdown in vivo leads to Gata4 downregulation and enhanced atrial septal defect (ASD) risk in mice. GATA4 is a fundamental TF in embryonic heart development and cardiac differentiation, and reduction in GATA4 function results in a diverse range of CHDs |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ZFPM2 | down-regulates activity
binding
|
GATA4 |
0.775 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-236959 |
|
|
Mus musculus |
NIH-3T3 Cell |
| pmid |
sentence |
| 9927675 |
FOG-2 associates physically with the N-terminal zinc finger of GATA-4 both in vitro and in vivo. This interaction appears to modulate specifically the transcriptional activity of GATA-4 because overexpression of FOG-2 in both NIH 3T3 cells and primary rat cardiomyocytes represses GATA-4-dependent transcription from multiple cardiac-restricted promoters. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
JARID2 | down-regulates activity
binding
|
GATA4 |
0.468 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-224697 |
|
|
Rattus norvegicus |
Cardiomyocyte Cell Line |
| pmid |
sentence |
| 15542826 |
JMJ physically associates with Nkx2.5 and GATA4 in vitro and in vivo as determined by glutathione S-transferase pull-down and immunoprecipitation assays. we show that JMJ represses ANF gene expression by inhibiting transcriptional activities of Nkx2.5 and GATA4. |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| + |
NKX2-5 | up-regulates quantity by expression
transcriptional regulation
|
GATA4 |
0.844 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253654 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19479054 |
Using antisense inhibition we disrupted the expression of NKX2-5 and studied changes in expression of cardiac-associated genes. Down-regulation of NKX2-5 resulted in increased beta-catenin while GATA4 was decreased. We demonstrated that this regulation was conferred by binding of NKX2-5 to specific elements (NKEs) in the promoter region of the beta-catenin and GATA4 genes. Using promoter-luciferase reporter assay combined with mutational analysis of the NKEs we demonstrated that the identified NKX2-5 binding sites were essential for the suppression of beta-catenin, and upregulation of GATA4 by NKX2-5. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GATA4 | up-regulates quantity by expression
transcriptional regulation
|
α-Catenin |
0.253 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265815 |
|
|
Homo sapiens |
Cardiac Muscle Fiber |
| pmid |
sentence |
| 21598020 |
GATA-4 and MEF2C are known to bind to the GATA box 2 in the major promoter of CTNNA3 and this element is essential in directly regulating expression of CTNNA3 in cardiac muscle cells. The co-transfection of GATA-4 with MEF2C leads to a synergistic activation of the CTNNA3 promoter |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ZBED1 | down-regulates quantity by repression
transcriptional regulation
|
GATA4 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-239736 |
|
|
Drosophila melanogaster |
Somatic Embryo |
| pmid |
sentence |
| 22021382 |
XNP/dATRX physically interacts with DREF. our results show that DREF is required for the proper expression of pnr and that XNP/dATRX binds to DREF at the DRE sites, resulting in the repression of pnr gene expression. |
|
| Publications: |
1 |
Organism: |
Drosophila Melanogaster |
| + |
ATRX | down-regulates quantity by repression
transcriptional regulation
|
GATA4 |
0.415 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-239733 |
|
|
Drosophila melanogaster |
Somatic Embryo |
| pmid |
sentence |
| 22021382 |
XNP/dATRX physically interacts with DREF. our results show that DREF is required for the proper expression of pnr and that XNP/dATRX binds to DREF at the DRE sites, resulting in the repression of pnr gene expression. |
|
| Publications: |
1 |
Organism: |
Drosophila Melanogaster |
| + |
HYDIN | up-regulates quantity by expression
transcriptional regulation
|
GATA4 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265479 |
|
|
Homo sapiens |
Embryonic Stem Cell |
| pmid |
sentence |
| 32376282 |
HYDIN promotes expression of Gata4 in cardiomyocyte differentiation. HYDIN functions as a positive regulator of human cardiomyocyte differentiation and promotes expression of cardiac contractile genes in hESC cells. This is mediated through GATA4, a critical transcription factor in heart development. Cardiac-specific Hydin knockdown in vivo leads to Gata4 downregulation and enhanced atrial septal defect (ASD) risk in mice. GATA4 is a fundamental TF in embryonic heart development and cardiac differentiation, and reduction in GATA4 function results in a diverse range of CHDs |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
GATA4
- 
- 