+ |
ABL1 | up-regulates quantity by stabilization
phosphorylation
|
CKMT1A |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-277406 |
Tyr153 |
ASKIRSGyFDERYVL |
Homo sapiens |
BT-474 Cell |
pmid |
sentence |
30174304 |
Here, we show that oncogenic HER2 tyrosine kinase signaling induces phosphorylation of mitochondrial creatine kinase 1 (MtCK1) on tyrosine 153 (Y153) in an ABL-dependent manner in breast cancer cells. Y153 phosphorylation, which is commonly upregulated in HER2+ breast cancers, stabilizes MtCK1 to increase the phosphocreatine energy shuttle and promote proliferation. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
CKMT1A | up-regulates quantity
chemical modification
|
N-phosphocreatine |
0.8 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-265790 |
|
|
Homo sapiens |
|
pmid |
sentence |
18502307 |
Creatine kinase catalyses the reversible transphosphorylation of creatine by ATP. In the cell, creatine kinase isoenzymes are specifically localized at strategic sites of ATP consumption to efficiently regenerate ATP in situ via phosphocreatine or at sites of ATP generation to build-up a phosphocreatine pool. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
creatine | up-regulates activity
chemical activation
|
CKMT1A |
0.8 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-265786 |
|
|
Homo sapiens |
|
pmid |
sentence |
18502307 |
Creatine kinase catalyses the reversible transphosphorylation of creatine by ATP. In the cell, creatine kinase isoenzymes are specifically localized at strategic sites of ATP consumption to efficiently regenerate ATP in situ via phosphocreatine or at sites of ATP generation to build-up a phosphocreatine pool. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |