| Name
|
 NR2C1
|
| Full Name |
Nuclear receptor subfamily 2 group C member 1 |
| Synonyms |
Orphan nuclear receptor TR2, Testicular receptor 2 | TR2 |
| Primary ID |
P13056 |
| Links |
 -  -  |
| Type |
protein |
| Relations |
1 |
| Function |
Orphan nuclear receptor. Binds the IR7 element in the promoter of its own gene in an autoregulatory negative feedback mechanism. Primarily repressor of a broad range of genes. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Together with NR2C2, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription. Also activator of OCT4 gene expression. May be involved in stem cell proliferation and differentiation. Mediator of retinoic acid-regulated preadipocyte proliferation. |
3.0
phosphorylation