Summary

Name IFI30
Full Name Gamma-interferon-inducible lysosomal thiol reductase
Synonyms Gamma-interferon-inducible protein IP-30, Legumaturain | GILT, IP30
Primary ID P13284
Links - -
Type protein
Relations 2
Function Lysosomal thiol reductase that can reduce protein disulfide bonds. May facilitate the complete unfolding of proteins destined for lysosomal degradation. Plays an important role in antigen processing. Facilitates the generation of MHC class II-restricted epitodes from disulfide bond-containing antigen by the endocytic reduction of disulfide bonds (By similarity). Facilitates also MHC class I-restricted recognition of exogenous antigens containing disulfide bonds by CD8+ T-cells or crosspresentation (By similarity).

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Relations

Regulator Mechanism target score
+ down-regulates quantity img/direct_inhibition.png chemical modification oligopeptide 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity img/direct-activation.png chemical modification peptide antigen 0.8
Publications: 1 Organism: Homo Sapiens