| + |
oligopeptide | up-regulates quantity 
precursor of
|
peptide antigen |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267863 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 31810556 |
Within the phagosome, the internalized antigens are partially degraded by Cathepsin S and the GILT complex, a necessary step for further export to cytosol. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267770 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 31810556 |
While peptides loaded onto MHC class I molecules are 8–11 amino acid residues long (a restriction based on the size and conformation of the peptide-binding groove of MHC class I molecules), peptides translocated by TAP can be significantly longer. These peptides will be trimmed to the correct length by ERAP-1. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267866 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 31810556 |
Within the phagosome, the internalized antigens are partially degraded by Cathepsin S and the GILT complex, a necessary step for further export to cytosol. |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| + |
ERAP2 | up-regulates quantity
chemical modification
|
peptide antigen |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272496 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15908954 |
The generation of many HLA class I peptides entails a final trimming step in the endoplasmic reticulum that, in humans, is accomplished by two 'candidate' aminopeptidases | We show here that one of these, ERAP1, was unable to remove several N-terminal amino acids that were trimmed efficiently by the second enzyme, ERAP2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
peptide antigen | form complex 
binding
|
Class II MHC:Antigen |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267871 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 33374673 |
The major histocompatibility complex (MHC) molecules, or human leukocyte antigens (HLA) in humans, bind these peptides to present them to T cells that recognise them with their surface T cell receptors (TCR). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ERAP1 | up-regulates quantity
chemical modification
|
peptide antigen |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267772 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 31810556 |
While peptides loaded onto MHC class I molecules are 8–11 amino acid residues long (a restriction based on the size and conformation of the peptide-binding groove of MHC class I molecules), peptides translocated by TAP can be significantly longer. These peptides will be trimmed to the correct length by ERAP-1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CTSS | up-regulates quantity
chemical modification
|
peptide antigen |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267867 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 31810556 |
Within the phagosome, the internalized antigens are partially degraded by Cathepsin S and the GILT complex, a necessary step for further export to cytosol. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
peptide antigen | form complex
binding
|
Class I MHC:Antigen |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267773 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 33374673 |
The major histocompatibility complex (MHC) molecules, or human leukocyte antigens (HLA) in humans, bind these peptides to present them to T cells that recognise them with their surface T cell receptors (TCR). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IFI30 | up-regulates quantity
chemical modification
|
peptide antigen |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267864 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 31810556 |
Within the phagosome, the internalized antigens are partially degraded by Cathepsin S and the GILT complex, a necessary step for further export to cytosol. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NPEPPS | up-regulates quantity
chemical modification
|
peptide antigen |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272468 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11062501 |
The proteasome generates exact major histocompatibility complex (MHC) class I ligands as well as NH2-terminal-extended precursor peptides| We performed in vitro peptide digests using recombinant PSA | PSA behaved exclusively as an aminopeptidase |BH and PSA act as complementary and redundant systems responsible for the final trimming of the correct NH2 terminus. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
peptide antigen