| + |
RFX1 | up-regulates quantity by expression 
transcriptional regulation
|
HLA-DOB |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254022 |
|
|
Homo sapiens |
B-lymphocyte |
| pmid |
sentence |
| 11823510 |
Class II transactivator is required for maximal expression of HLA-DOB in B cells|HLA-DO, encoded by the HLA-DOA and HLA-DOB genes, has been shown to function as a modulator of Ag presentation. DNA microarray comparisons between B cells wild-type and mutant for the master regulator of MHC class II transcription, class II transactivator (CIITA), identified HLA-DOA and HLA-DOB as being up-regulated by CIITA. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RFX complex | up-regulates quantity by expression
transcriptional regulation
|
HLA-DOB |
0.262 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254000 |
|
|
in vitro |
|
| pmid |
sentence |
| 11258423 |
The RFX complex is comprised of three proteins – RFX5, RFXB, and RFXAP – all of which are required for expression of MHCII genes|In our current studies, we have utilized electrophoretic mobility shift assays to characterize the DNA binding of the RFX5(1–330)2•RFXAP•RFXB complex to the proximal regulatory region from the HLA-DRα gene to gain insight into the DNA binding properties of the RFX complex |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
CIITA | up-regulates quantity by expression
transcriptional regulation
|
HLA-DOB |
0.32 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254015 |
|
|
Homo sapiens |
B-lymphocyte |
| pmid |
sentence |
| 11823510 |
Class II transactivator is required for maximal expression of HLA-DOB in B cells|HLA-DO, encoded by the HLA-DOA and HLA-DOB genes, has been shown to function as a modulator of Ag presentation. DNA microarray comparisons between B cells wild-type and mutant for the master regulator of MHC class II transcription, class II transactivator (CIITA), identified HLA-DOA and HLA-DOB as being up-regulated by CIITA. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
HLA-DOB
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