| + |
RFX1 | up-regulates quantity by expression 
transcriptional regulation
|
HLA-DOB |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254022 |
|
|
Homo sapiens |
B-lymphocyte |
| pmid |
sentence |
| 11823510 |
Class II transactivator is required for maximal expression of HLA-DOB in B cells|HLA-DO, encoded by the HLA-DOA and HLA-DOB genes, has been shown to function as a modulator of Ag presentation. DNA microarray comparisons between B cells wild-type and mutant for the master regulator of MHC class II transcription, class II transactivator (CIITA), identified HLA-DOA and HLA-DOB as being up-regulated by CIITA. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RFX1 | up-regulates 
binding
|
ABL1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-57516 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9583676 |
We show that rfxi and c-abl are in direct interaction, in vitro and in cell extracts, through the rfxi proline rich (pxxp) motif and the c-abl sh3 domain. Remarkably, this interaction significantly potentiates c-abl but not v-abl auto-kinase activity |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RFX1 | down-regulates quantity by repression 
transcriptional regulation
|
MYC |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253829 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12032779 |
Several different transcription factors have been implicated in the down-regulation of c-myc expression during differentiation, including C/EBPalpha, CTCF, BLIMP-1, and RFX1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
RFX1
- 
- 