| + |
HMGB1 | up-regulates activity 
binding
|
HOXB1 |
0.301 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-219853 |
|
|
in vitro |
|
| pmid |
sentence |
| 8890171 |
We show that HMG1 interacts with proteins encoded by the HOX gene family by establishing protein-protein contacts between the HMG box domains and the HOX homeodomain. The functional role of these interactions was studied using the transcriptional activity of the human HOXD9 protein as a model. HMG1 enhances, in a dose-dependent fashion, the sequence-specific DNA binding activity in vitro, and the transcriptional activation in a co-transfection assay in vivo, of the HOXD9 protein. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
HOXB1 | up-regulates quantity by expression
transcriptional regulation
|
OTX2 |
0.278 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261633 |
|
|
Homo sapiens |
NT2/D1 Cell |
| pmid |
sentence |
| 9556594 |
Transactivation of the mouse OTX2 Luc constructs by the human HOXB1, HOXB2, and HOXB3 proteins. | Likewise, the construct pOTX2LucΔ−710 showed an 8-, 12-, and 6-fold increase in transcriptional activity if co-transfected with pSG-HOXB1, -HOXB2, and -HOXB3, respectively |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PKNOX1 | up-regulates activity
binding
|
HOXB1 |
0.598 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-241215 |
|
|
in vitro |
|
| pmid |
sentence |
| 9482740 |
we observe the formation of a ternary Prep1-Pbx1-HOXB1 complex on a HOXB1-responsive target in vitro. Interaction with Prep1 enhances the ability of the HOXB1-Pbx1 complex to activate transcription in a cooperative fashion from the same target. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
PBX1 | up-regulates activity
binding
|
HOXB1 |
0.799 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-241219 |
|
|
in vitro |
|
| pmid |
sentence |
| 10052460 |
Pbx1 and exd act as cofactors that enhance the DNA binding specificity of Hox proteins. The structure of the HoxB1Pbx1DNA ternary complex shows that HoxB1 and Pbx1 bind to overlapping binding sites located on opposite faces of the DNA. |
|
| Publications: |
1 |
Organism: |
In Vitro |
3.0
HOXB1
- 
- 