| + |
SOX2/POU5F1 | up-regulates quantity by expression 
transcriptional regulation
|
OTX2 |
0.476 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269240 |
|
|
|
|
| pmid |
sentence |
| 31583686 |
Both SOX2 and SOX17 are able to partner with OCT4 and, as a consequence, recognize and bind specific binding motifs.6, 7 In human and mouse ESCs, SOX2/OCT4 bind to canonical motifs (CTTTGTCATGCAAAT-like), which are composite SOX (CATTGTC-like) and OCT (ATGCAAAT-like) motifs|This way SOX17 and SOX2 regulate a common set of pluripotency and GC-related genes (PRDM14, DPPA4, TDGF1, NANOG, LIN28A, TRIM71, OTX2, PIM2) (Fig. 6). Additionally, in TCam-2 cells SOX17 binds to compressed motifs or SOX motifs (not bound by SOX2 in ECs), thereby regulating the PGC specifiers PRDM1 and TFAP2C, the GC-related genes NANOS3 and BMP7 and the cancer-related genes MYC and IGF1 (Fig. 6). In 2102EP cells, SOX2 further binds canonical elements or SOX motifs (not bound by SOX17 in TCam-2), regulating additional pluripotency genes (GDF3, LEFTY2, SALL4, SOX2 and POU5F1) (Fig. 6). |
|
| Publications: |
1 |
| + |
OTX2 | up-regulates quantity by expression 
transcriptional regulation
|
BEST1 |
0.359 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255186 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 20530484 |
BEST1 promoter activity was increased by SOX9 overexpression and decreased by siRNA-mediated SOX9 knockdown. SOX9 physically interacted with MITF and OTX2 and orchestrated synergistic activation of the BEST1 promoter with the paired SOX site playing essential roles. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254888 |
|
|
in vitro |
|
| pmid |
sentence |
| 18849347 |
Three OTX family proteins - OTX1, OTX2 and CRX - bound to both Sites 1 and 2 in vitro, and all of them increased BEST1 promoter activity. |
|
| Publications: |
2 |
Organism: |
Mus Musculus, In Vitro |
| + |
HOXB1 | up-regulates quantity by expression
transcriptional regulation
|
OTX2 |
0.278 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261633 |
|
|
Homo sapiens |
NT2/D1 Cell |
| pmid |
sentence |
| 9556594 |
Transactivation of the mouse OTX2 Luc constructs by the human HOXB1, HOXB2, and HOXB3 proteins. | Likewise, the construct pOTX2LucΔ−710 showed an 8-, 12-, and 6-fold increase in transcriptional activity if co-transfected with pSG-HOXB1, -HOXB2, and -HOXB3, respectively |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SOX9 | up-regulates activity
binding
|
OTX2 |
0.358 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255184 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 20530484 |
BEST1 promoter activity was increased by SOX9 overexpression and decreased by siRNA-mediated SOX9 knockdown. SOX9 physically interacted with MITF and OTX2 and orchestrated synergistic activation of the BEST1 promoter with the paired SOX site playing essential roles. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
LHX1 | up-regulates activity
binding
|
OTX2 |
0.445 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-221161 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 10623575 |
Here we show that OTX2 directly associates with LIM1 and HNF-3beta. The luciferase assay with the P3C sequence, a specific DNA binding sequence for paired-class homeobox genes, has demonstrated that LIM1 enhances, but HNF-3beta represses, OTX2-directed gene expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SOX17/POU5F1 | up-regulates quantity by expression
transcriptional regulation
|
OTX2 |
0.44 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269248 |
|
|
|
|
| pmid |
sentence |
| 31583686 |
Both SOX2 and SOX17 are able to partner with OCT4 and, as a consequence, recognize and bind specific binding motifs.6, 7 In human and mouse ESCs, SOX2/OCT4 bind to canonical motifs (CTTTGTCATGCAAAT-like), which are composite SOX (CATTGTC-like) and OCT (ATGCAAAT-like) motifs|This way SOX17 and SOX2 regulate a common set of pluripotency and GC-related genes (PRDM14, DPPA4, TDGF1, NANOG, LIN28A, TRIM71, OTX2, PIM2) (Fig. 6). Additionally, in TCam-2 cells SOX17 binds to compressed motifs or SOX motifs (not bound by SOX2 in ECs), thereby regulating the PGC specifiers PRDM1 and TFAP2C, the GC-related genes NANOS3 and BMP7 and the cancer-related genes MYC and IGF1 (Fig. 6). In 2102EP cells, SOX2 further binds canonical elements or SOX motifs (not bound by SOX17 in TCam-2), regulating additional pluripotency genes (GDF3, LEFTY2, SALL4, SOX2 and POU5F1) (Fig. 6). |
|
| Publications: |
1 |
| + |
OTX2 | up-regulates quantity by expression
transcriptional regulation
|
RBP3 |
0.311 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254889 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10354480 |
OTX2, as well as CRX, a homeodomain protein very similar to OTX2, activates the human IRBP promoter in co-transfection experiments. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HOXB2 | up-regulates quantity by expression
transcriptional regulation
|
OTX2 |
0.262 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261634 |
|
|
Homo sapiens |
NT2/D1 Cell |
| pmid |
sentence |
| 9556594 |
Transactivation of the mouse OTX2 Luc constructs by the human HOXB1, HOXB2, and HOXB3 proteins. | Likewise, the construct pOTX2LucΔ−710 showed an 8-, 12-, and 6-fold increase in transcriptional activity if co-transfected with pSG-HOXB1, -HOXB2, and -HOXB3, respectively |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FOXA2 | down-regulates activity 
binding
|
OTX2 |
0.565 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-221164 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 10623575 |
Here we show that OTX2 directly associates with LIM1 and HNF-3beta. The luciferase assay with the P3C sequence, a specific DNA binding sequence for paired-class homeobox genes, has demonstrated that LIM1 enhances, but HNF-3beta represses, OTX2-directed gene expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HOXB3 | up-regulates quantity by expression
transcriptional regulation
|
OTX2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261635 |
|
|
Homo sapiens |
NT2/D1 Cell |
| pmid |
sentence |
| 9556594 |
Transactivation of the mouse OTX2 Luc constructs by the human HOXB1, HOXB2, and HOXB3 proteins. | Likewise, the construct pOTX2LucΔ−710 showed an 8-, 12-, and 6-fold increase in transcriptional activity if co-transfected with pSG-HOXB1, -HOXB2, and -HOXB3, respectively |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
OTX2
- 
- 