| + |
NR5A2 | up-regulates quantity by expression 
transcriptional regulation
|
CYP11B1 |
0.349 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254880 |
|
|
Homo sapiens |
NCI-H295R Cell |
| pmid |
sentence |
| 11564608 |
The ability of LRH-1 to enhance transcription of the gene encoding human 11 beta- hydroxylase (hCYP11B1) was then examined using the H295R adrenal cell line. LRH-1 co-transfection with hCYP11B1 luciferase promoter constructs caused a 25-fold induction of luciferase activity. Furthermore, co-transfection of a hCYP11B1 reporter construct containing a mutation in the SF-1 binding cis-element abolished the stimulatory effect of both SF-1 and LRH-1. Electrophoretic mobility shift assay (EMSA) demonstrated that LRH-1 could bind to the SF-1 response element. Taken together, our data suggested that LRH-1 is expressed in the adrenal, and can substitute for SF-1 to enhance transcription of genes encoding certain of the steroid-metabolizing enzymes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CYP11B1 | down-regulates quantity 
chemical modification
|
11-deoxycortisol |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268679 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9814482 |
Recombinant CYP11B genes encode enzymes that can catalyze conversion of 11-deoxycortisol to cortisol, 18-hydroxycortisol, and 18-oxocortisol. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Zona Fasciculata |
| Pathways: | Sex Hormone Biosynthesis |
| + |
CYP11B1 | up-regulates quantity 
chemical modification
|
corticosterone |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268682 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 33117906 |
The zona glomerulosa lacks the 17alpha-hydroxylase enzyme, committing pregnenolone to the exclusive production of aldosterone.|In the adrenal steroidogenic pathway, 21-hydroxylase (P450c21) catalyzes the conversion of 17-hydroxyprogesterone (17OHP) to 11-deoxycortisol to form cortisol and the conversion of progesterone to 11-deoxycorticosterone to form aldosterone |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Zona Glomerulosa |
| Pathways: | Sex Hormone Biosynthesis |
| + |
CYP11B1 | down-regulates quantity
chemical modification
|
11-deoxycorticosterone |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268683 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 33117906 |
The zona glomerulosa lacks the 17alpha-hydroxylase enzyme, committing pregnenolone to the exclusive production of aldosterone.|In the adrenal steroidogenic pathway, 21-hydroxylase (P450c21) catalyzes the conversion of 17-hydroxyprogesterone (17OHP) to 11-deoxycortisol to form cortisol and the conversion of progesterone to 11-deoxycorticosterone to form aldosterone |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Zona Glomerulosa |
| Pathways: | Sex Hormone Biosynthesis |
| + |
CYP11B1 | up-regulates quantity
chemical modification
|
cortisol |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268678 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9814482 |
Recombinant CYP11B genes encode enzymes that can catalyze conversion of 11-deoxycortisol to cortisol, 18-hydroxycortisol, and 18-oxocortisol. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Zona Fasciculata |
| Pathways: | Sex Hormone Biosynthesis |
| + |
metyrapone | down-regulates activity
chemical inhibition
|
CYP11B1 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-257884 |
|
|
in vitro |
|
| pmid |
sentence |
| 21129965 |
In an effort to develop and evaluate new classes of compounds as CYP inhibitors, we based our investigations on the structure of the well-known CYP inhibitor Metyrapone 2, which has been used for the treatment of hypercortisolism and Cushing’ssyndrome for several decades. |
|
| Publications: |
1 |
Organism: |
In Vitro |
3.0
CYP11B1
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