| + |
PKA | up-regulates activity 
phosphorylation
|
NR5A2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276041 |
Ser510 |
LPEIRAIsMQAEEYL |
Homo sapiens |
MCF-7 Cell |
| pmid |
sentence |
| 16109788 |
PKA-mediated phosphorylation increases the interaction between GATA3 and LRH-1 and the requirement for PKA in aromatase PII promoter stimulation involves at least three specific amino acid residues: GATA3 Ser308, GATA4 Ser261, and LRH-1 Ser469. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NR5A2 | up-regulates quantity by expression 
transcriptional regulation
|
CYP11B1 |
0.349 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254880 |
|
|
Homo sapiens |
NCI-H295R Cell |
| pmid |
sentence |
| 11564608 |
The ability of LRH-1 to enhance transcription of the gene encoding human 11 beta- hydroxylase (hCYP11B1) was then examined using the H295R adrenal cell line. LRH-1 co-transfection with hCYP11B1 luciferase promoter constructs caused a 25-fold induction of luciferase activity. Furthermore, co-transfection of a hCYP11B1 reporter construct containing a mutation in the SF-1 binding cis-element abolished the stimulatory effect of both SF-1 and LRH-1. Electrophoretic mobility shift assay (EMSA) demonstrated that LRH-1 could bind to the SF-1 response element. Taken together, our data suggested that LRH-1 is expressed in the adrenal, and can substitute for SF-1 to enhance transcription of genes encoding certain of the steroid-metabolizing enzymes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NR0B2 | down-regulates 
binding
|
NR5A2 |
0.579 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-134202 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15723037 |
Modulation of human nuclear receptor lrh-1 activity by phospholipids and shpthe human nuclear receptor liver receptor homolog 1 (hlrh-1) plays an important role in the development of breast carcinomas. This orphan receptor is efficiently downregulated by the unusual co-repressor shp |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-92060 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12198243 |
Here we show that shp can interact with the liver x receptors lxralpha (nr1h3) and lxrbeta (nr1h2), as demonstrated by glutathione-s-transferase pull-down assays, mammalian two-hybrid, and coimmunoprecipitation experiments. In transfection assays, shp inhibits the expression of an artificial reporter driven by an lxr-response element and represses the transcriptional activation by lxr of the human atp-binding cassette transporter 1 (abca1) promoter |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
NR5A2 | up-regulates quantity by expression
transcriptional regulation
|
HSD3B2 |
0.371 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254873 |
|
|
Homo sapiens |
Endometrial Cancer Cell Line |
| pmid |
sentence |
| 19022561 |
We found that both SF1 and LRH1 can transcriptionally cooperate with the AP-1 family members c-JUN and c-FOS, known to be associated with enhanced proliferation of endometrial carcinoma cells, to further enhance activation of the STAR, HSD3B2, and CYP19A1 PII promoters. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NR5A2 | up-regulates quantity by expression
transcriptional regulation
|
CYP19A1 |
0.418 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254872 |
|
|
Homo sapiens |
Endometrial Cancer Cell Line |
| pmid |
sentence |
| 19022561 |
We found that both SF1 and LRH1 can transcriptionally cooperate with the AP-1 family members c-JUN and c-FOS, known to be associated with enhanced proliferation of endometrial carcinoma cells, to further enhance activation of the STAR, HSD3B2, and CYP19A1 PII promoters. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NR5A2 | up-regulates quantity by expression
transcriptional regulation
|
STAR |
0.358 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254870 |
|
|
Homo sapiens |
Endometrial Cancer Cell Line |
| pmid |
sentence |
| 19022561 |
We found that both SF1 and LRH1 can transcriptionally cooperate with the AP-1 family members c-JUN and c-FOS, known to be associated with enhanced proliferation of endometrial carcinoma cells, to further enhance activation of the STAR, HSD3B2, and CYP19A1 PII promoters. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
NR5A2
- 
- 