Summary

Name NQO1
Full Name NAD
Synonyms Azoreductase, DT-diaphorase, DTD, Menadione reductase, NAD(P)H:quinone oxidoreductase 1, Phylloquinone reductase, Quinone reductase 1, QR1 | DIA4, NMOR1
Primary ID P15559
Links - -
Type protein
Relations 10
Pathways GPCR_HCC, Hepatocellular Tumor
Inhibitors vadimezan
Function The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinons involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.

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▶Modifications Tables

Relations

Regulator Mechanism target score ℹ
+ AKT1down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation NQO1 0.371
Publications: 2 Organism: Homo Sapiens
+ vadimezandown-regulates img/direct_inhibition.png chemical inhibition NQO1 0.8
Publications: 1 Organism: Homo Sapiens
+ NFE2L3down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation NQO1 0.339
Publications: 1
+ NFE2L2up-regulates quantity by expression img/indirect-activation.png transcriptional regulation NQO1 0.489
Publications: 1 Organism: Homo Sapiens
Pathways:Hepatocellular Tumor
+ NQO1up-regulates img/indirect-activation.png Proliferation 0.7
Publications: 2 Organism: Homo Sapiens
Pathways:Hepatocellular Tumor
+ NFE2L3down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation NQO1 0.339
Publications: 1
+ NFE2L1up-regulates quantity by expression img/indirect-activation.png transcriptional regulation NQO1 0.386
Publications: 1 Organism: Homo Sapiens
+ NFE2L2up-regulates quantity by expression img/direct-activation.png transcriptional regulation NQO1 0.489
Publications: 1 Organism: Homo Sapiens
Pathways:Hepatocellular Tumor