Relation Results

Summary

Name CHN1
Full Name N-chimaerin
Synonyms A-chimaerin, Alpha-chimerin, N-chimerin, NC, Rho GTPase-activating protein 2 | ARHGAP2, CHN
Primary ID P15882
Links - -
Type protein
Relations 2
Function GTPase-activating protein for p21-rac and a phorbol ester receptor. Involved in the assembly of neuronal locomotor circuits as a direct effector of EP ...
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Type: Score: Layout: SPV 
0.3440.652CHN1CDK5R1RAC1

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Relations
Regulator
Mechanism
target
score ℹ
+ CHN1up-regulates img/direct-activation.png binding CDK5R1 0.344
Identifier Residue Sequence Organism Cell Line
SIGNOR-123439 Homo sapiens
pmid sentence
_-chimaerin was identified to interact with the p35 activator of cdk5. The complex of _-chimaerin, cdk5 and p35 is enzymatically functional
Publications: 1 Organism: Homo Sapiens
+ CHN1down-regulates activity img/direct_inhibition.png gtpase-activating protein RAC1 0.652
Identifier Residue Sequence Organism Cell Line
SIGNOR-260499 Homo sapiens
pmid sentence
We therefore developed a screening-compatible live-cell imaging assay, using FRET-based biosensors for the prototype GTPases RHOA, RAC1 and CDC4215,19,20 (Extended Data Fig. 2 and Supplementary Note 1)|We found catalytic activities for 45/75 RhoGEFs and 48/63 RhoGAPs| Our data thus not only reveal extensive promiscuity among regulators, but also that the inactivating RhoGAPs are less selective than the activating RhoGEFs (p-value=0.02)(Supplementary Table 2).
Publications: 1 Organism: Homo Sapiens
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