Summary

Name ACADS
Full Name Short-chain specific acyl-CoA dehydrogenase, mitochondrial
Synonyms SCAD, EC 1.3.8.1, Butyryl-CoA dehydrogenase |
Primary ID P16219
Links - -
Type protein
Relations 8
Pathways Fatty Acid Beta-Oxidation
Function Short-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats (By similarity). The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA (By similarity). Among the different mitochondrial acyl-CoA dehydrogenases, short-chain specific acyl-CoA dehydrogenase acts specifically on acyl-CoAs with saturated 4 to 6 carbons long primary chains (PubMed:11134486, PubMed:21237683). {ECO:0000250|UniProtKB:P15651, ECO:0000269|PubMed:11134486, ECO:0000269|PubMed:21237683}.

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Relations

Regulator Mechanism target score ℹ
+ ACADSdown-regulates quantity img/direct_inhibition.png chemical modification hexanoyl-CoA(4-) 0.8
Publications: 1 Organism: Homo Sapiens
+ ACADSup-regulates quantity img/direct-activation.png chemical modification trans-hex-2-enoyl-CoA(4-) 0.8
Publications: 1 Organism: Homo Sapiens
+ ACADSup-regulates quantity img/direct-activation.png chemical modification FADH2(2-) 0.8
Publications: 2 Organism: Homo Sapiens
+ ACADSdown-regulates quantity img/direct_inhibition.png chemical modification butyryl-CoA(4-) 0.8
Publications: 1 Organism: Homo Sapiens
+ ACADSdown-regulates quantity img/direct_inhibition.png chemical modification FAD(3-) 0.8
Publications: 2 Organism: Homo Sapiens
+ ACADSup-regulates quantity img/direct-activation.png chemical modification crotonoyl-CoA(4-) 0.8
Publications: 1 Organism: Homo Sapiens