4.0
Summary
| Name |  EPCAM
|
| Full Name | Epithelial cell adhesion molecule |
| Synonyms | Ep-CAM, Adenocarcinoma-associated antigen, Cell surface glycoprotein Trop-1, Epithelial cell surface antigen, Epithelial glycoprotein, EGP, Epithelial glycoprotein 314, EGP314, hEGP314, KS 1/4 antigen, KSA, Major gastrointestinal tumor-associated protein GA733-2, Tumor-associated calcium signal transducer 1 | GA733-2, M1S2, M4S1, MIC18, TACSTD1, TROP1 |
| Primary ID | P16422 |
| Links |  -  -  |
| Type | protein |
| Relations | 3 |
| Function | May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E. |
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Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | ZEB1 | down-regulates quantity by repression 
transcriptional regulation
|
EPCAM | 0.432 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | NfKb-p65/p50 | down-regulates quantity by repression
transcriptional regulation
|
EPCAM | 0.283 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CBP/p300 | up-regulates quantity by expression 
transcriptional regulation
|
EPCAM | 0.254 |
| Publications: | 1 | Organism: | Homo Sapiens | |