| + |
CRIP1 | up-regulates activity 
binding
|
NfKb-p65/p50 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282635 |
|
|
Homo sapiens |
PANC-1 Cell |
| pmid |
sentence |
| 37541772 |
Our results showed that CRIP1 was frequently upregulated in PDAC tissues with low immune activation. Elevated CRIP1 expression induced high levels of myeloid-derived suppressor cell (MDSC) infiltration and fostered an immunosuppressive tumour microenvironment. Mechanistically, we primarily showed that CRIP1 bound to nuclear factor kappa-B (NF-κB)/p65 and facilitated its nuclear translocation in an importin-dependent manner, leading to the transcriptional activation of CXCL1/5. PDAC-derived CXCL1/5 facilitated the chemotactic migration of MDSCs to drive immunosuppression. SX-682, an inhibitor of CXCR1/2, blocked tumour MDSC recruitment and enhanced T-cell activation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NfKb-p65/p50 | up-regulates quantity by expression
transcriptional regulation
|
CXCL1 |
0.522 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282636 |
|
|
Homo sapiens |
PANC-1 Cell |
| pmid |
sentence |
| 37541772 |
Our results showed that CRIP1 was frequently upregulated in PDAC tissues with low immune activation. Elevated CRIP1 expression induced high levels of myeloid-derived suppressor cell (MDSC) infiltration and fostered an immunosuppressive tumour microenvironment. Mechanistically, we primarily showed that CRIP1 bound to nuclear factor kappa-B (NF-κB)/p65 and facilitated its nuclear translocation in an importin-dependent manner, leading to the transcriptional activation of CXCL1/5. PDAC-derived CXCL1/5 facilitated the chemotactic migration of MDSCs to drive immunosuppression. SX-682, an inhibitor of CXCR1/2, blocked tumour MDSC recruitment and enhanced T-cell activation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NfKb-p65/p50 | up-regulates quantity by expression 
transcriptional regulation
|
ABCB1 |
0.26 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254654 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19763573 |
PSC833, cyclosporine analogue, downregulates MDR1 expression by activating JNK/c-Jun/AP-1 and suppressing NF-kappaB. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CASP8AP2 | up-regulates
binding
|
NfKb-p65/p50 |
0.245 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-217385 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22075988 |
In addition, both cleavage products of c-flip turned out to be inducers of nf-kb activity by binding to the ikk complex. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IKBKB | down-regulates 
phosphorylation
|
NfKb-p65/p50 |
0.875 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-217403 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11158290 |
Ikkbeta phosphorylates p105 resulting in its degradation, which releases tpl2 resulting in activation of the pro-proliferative map kinase- pathway. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-217400 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10469655 |
Ikkbeta phosphorylates p105 resulting in its degradation, which releases tpl2 resulting in activation of the pro-proliferative map kinase- pathway. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | FLT3-ITD signaling |
| + |
NfKb-p65/p50 | up-regulates quantity by expression
transcriptional regulation
|
F3 |
0.248 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254810 |
|
|
Homo sapiens |
HUVEC Cell |
| pmid |
sentence |
| 12744731 |
In conclusion, NF-kappaB could be activated promptly after HUVEC incubated with TNF-alpha, then it was bound to TF promotor to start the TF transcription, TF mRNA expression was upregulated, that leaded to the increase of TF expression on the HUVEC surface and activated the coagulation cascade. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GSK3B | up-regulates
phosphorylation
|
NfKb-p65/p50 |
0.365 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-217367 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17183360 |
Rela is phosphorylated at: ser276 by the catalytic subunit of protein kinase a (pkac), msk1 and msk2; at ser311 by the atypical pkczeta; at ser468 by ikkbeta, ikkepsilon and glycogen-synthase kinase-3beta (gsk3beta); at ser529 by ck2; and at ser536 by ikkbeta, ikkalfa, ikkepsilon, nf-kb activating kinase (nak, also known as tank-binding kinase-1 tbk1)) and rsk1 (also known as p90 ribosomal protein s6 kinase (p90s6k) . |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-217430 |
|
|
Homo sapiens |
T-lymphocyte |
| pmid |
sentence |
| 16407239 |
Rela is phosphorylated at: ser276 by the catalytic subunit of protein kinase a (pkac), msk1 and msk2; at ser311 by the atypical pkczeta; at ser468 by ikkbeta, ikkepsilon and glycogen-synthase kinase-3beta (gsk3beta); at ser529 by ck2; and at ser536 by ikkbeta, ikkalfa, ikkepsilon, nf-kb activating kinase (nak, also known as tank-binding kinase-1 tbk1)) and rsk1 (also known as p90 ribosomal protein s6 kinase (p90s6k) . |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, FLT3-ITD signaling |
| + |
NfKb-p65/p50 | up-regulates quantity by expression
transcriptional regulation
|
MDM2 |
0.366 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-168296 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20921405 |
Nf-kb activation following t-cell receptor engagement induces the expression of mdm2 through interaction with nf-kb sites in its p1 promoter |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, miRNA in AML, FLT3-ITD signaling, Pancreatic ductal adenocarcinoma (PDA) |
| + |
PRKACA | up-regulates
phosphorylation
|
NfKb-p65/p50 |
0.53 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-217391 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17959673 |
In this study, we demonstrate that the phosphorylation of p50 and p65 by the catalytic subunit of protein kinase a (pkac) is essential for nf-kappab dna binding and transactivation activity. treatment with h89 and knockdown of pkac in cells led to the inhibition of phosphorylation at p50 ser(337) and p65 ser(276) and loss of dna binding by nf-kappab. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-217364 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9660950 |
The transcriptional activity of nf-kappa b is stimulated upon phosphorylation of its p65 subunit on serine 276 by protein kinase a (pka). |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network |
| + |
NfKb-p65/p50 | up-regulates quantity by expression
transcriptional regulation
|
HYAL1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253880 |
|
|
Homo sapiens |
253J Cell |
| pmid |
sentence |
| 18718911 |
In 253J-Lung and HT1376 bladder cancer cell lines, which show high HYAL-1 expression, transcription factors Egr-1, AP-2, and NFκB bind the HYAL-1 promoter. Because both SP1 and Egr-1 have two overlapping binding sites within the promoter (Fig. 5), it appears that although SP1 binding to the methylated HYAL-1 promoter turns off transcription, binding of Erg-1 (and also AP-2) to the unmethylated promoter turns on transcription. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NfKb-p65/p50 | up-regulates
binding
|
EGR1 |
0.39 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-216328 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10671503 |
The early growth response transcription factor egr-1 can also interact with rela in vitro and regulate nf-kappab transcriptional activity in vivo |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NfKb-p65/p50 | up-regulates quantity by expression
transcriptional regulation
|
S100A6 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254803 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12859951 |
NF-kappaB transcription factor contributes to the activation of S100A6 gene expression in response to TNFalpha in HepG2 cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TNF | up-regulates activity
|
NfKb-p65/p50 |
0.695 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255689 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 8530143 |
Data from our laboratory demonstrate that the TNF signal transduction pathway-mediating NF-kappa B activation involves two phospholipases, a phosphatidylcholine-specific phospholipase C (PC-PLC) and an endosomal acidic sphingomyelinase (aSMase). The aSMase activation by TNF is secondary to the generation of 1,2-diacylglycerol (DAG) produced by a TNF-responsive PC-PLC. SMase and its product ceramide induce degradation of the NF-kappa B inhibitor I kappa B as well as NF-kappa B activation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network, EBV infection, Inflammosome Activation, Inhibition of Apoptosis, Multiple sclerosis, NF-KB Canonical, SARS-CoV CYTOKINE STORM, SARS-CoV INFLAMMATORY RESPONSE, TNF-alpha Signaling |
| + |
NfKb-p65/p50 | up-regulates quantity by expression
transcriptional regulation
|
CD86 |
0.289 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254782 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19164127 |
We found that upon TLR7 and TLR8 activation, JNK and NF-kappaB positively regulated the expression of CCR7, CD86, CD83, and CD40 and the production of IL-6 and IL-12p40. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PPARGC1A | down-regulates quantity by repression 
transcriptional regulation
|
NfKb-p65/p50 |
0.357 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-217978 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 20404331 |
In mouse muscles, overexpression of PGC-1beta (like PGC-1alpha) inhibited denervation atrophy, ubiquitin ligase induction, and transcription by NFkappaB |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Tissue: |
Skeletal Muscle |
| + |
NfKb-p65/p50 | up-regulates quantity by expression
transcriptional regulation
|
CCL2 |
0.596 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255356 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20219869 |
Once in the nucleus, NF-kB can induce the transcription of iNOS, TNF-alpha, and IL-1, which may then promote further NF-kB activation, as well as elevate the expression of other inflammatory mediators such as CCL2 and IL-6. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Skeletal Muscle |
| Pathways: | COVID-19 Causal Network, Inflammosome Activation, SARS-CoV CYTOKINE STORM, SARS-CoV INFLAMMATORY RESPONSE |
| + |
MAP3K7 | up-regulates activity
|
NfKb-p65/p50 |
0.669 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-55710 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9480845 |
Overexpression of tak1 together with its activator protein, tak1 binding protein 1 (tab1), induced the nuclear translocation of nf-kappa b p50/p65 heterodimer accompanied by the degradation of i kappa b alpha and i kappa b beta, and the expression of kappa b-dependent reporter gene...[]...These Results suggest that tak1 induces nf-kappa b activation through a novel nik-independent signaling pathway |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network, EBV infection, IL1 Signaling , Inflammosome Activation, Inhibition of Apoptosis, NF-KB Canonical, SARS-CoV INFLAMMATORY RESPONSE, Toll like receptors |
| + |
NfKb-p65/p50 | up-regulates quantity by expression
transcriptional regulation
|
HSD11B2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253877 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15659537 |
Overexpression of p50 inhibited HSD11B2 promoter activity and overexpression of Egr-1 inhibited transactivation of the HSD11B2 promoter by p65/p50. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NfKb-p65/p50 | up-regulates quantity by expression
transcriptional regulation
|
KLK3 |
0.263 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253667 |
|
|
Homo sapiens |
LNCaP Cell |
| pmid |
sentence |
| 11909978 |
NF-kappa B activates prostate-specific antigen expression and is upregulated in androgen-independent prostate cancer. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NfKb-p65/p50 | up-regulates quantity by expression
transcriptional regulation
|
CD83 |
0.258 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254781 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19164127 |
We found that upon TLR7 and TLR8 activation, JNK and NF-kappaB positively regulated the expression of CCR7, CD86, CD83, and CD40 and the production of IL-6 and IL-12p40. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NfKb-p65/p50 | up-regulates
|
Immune_response |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-216319 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12692549 |
The transcription factors interferon regulatory factor 3 (IRF3) and NF-B are required for the expression of many genes involved in the innate immune response. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | B-cell activation, COVID-19 Causal Network, EBV infection, Innate Immune Response, Inflammosome Activation, Multiple sclerosis, SARS-CoV CYTOKINE STORM, SARS-CoV INFLAMMATORY RESPONSE, SARS-CoV INNATE RESPONSE TO dsRNA, SARS-CoV STRESS GRANULES, T cell activation, Toll like receptors |
| + |
NfKb-p65/p50 | up-regulates
|
Proliferation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-245043 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11359934 |
The nuclear factor-kappaB (NF-kappaB) family of transcription factors has been shown to regulate proliferation in several cell types. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255692 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22021368 |
In normal hematopoiesis, AML1 suppresses NF-κB signaling and thus may contribute to inhibition of excessive proliferation of hematopoietic cells. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, miRNA in AML, B-cell activation, COVID-19 Causal Network, EBV infection, FLT3-ITD signaling, Glucocorticoid receptor Signaling, NF-KB Canonical, Pancreatic ductal adenocarcinoma (PDA), TNF-alpha Signaling |
| + |
KDM2A | down-regulates
demethylation
|
NfKb-p65/p50 |
0.449 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-217415 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20080798 |
Fbxl11 and nsd1 have opposite effects on nf-kb; both bind to p65 subunit after activation of nf-kb. / nsd1 activates nf-kb and reverses the inhibitory effect of fbxl11 / these data confirm that fbxl11 and nsd1 constitute an enzyme pair that methylates and demethylates p65 on k218 and 221 in response to cytokine stimulation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IFNG | down-regulates activity
|
NfKb-p65/p50 |
0.456 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255937 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 23667107 |
Early inhibition of IL-1β expression by IFN-γ is mediated by impaired binding of NF-κB to the IL-1β promoter but is independent of nitric oxide. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Macrophage polarization, Multiple sclerosis, SARS-CoV CYTOKINE STORM |
| + |
IL17R complex | up-regulates activity
|
NfKb-p65/p50 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261338 |
|
|
Mus musculus |
NIH-3T3 Cell |
| pmid |
sentence |
| 8777726 |
3T3 cells were preincubated with an IL-17Rspecific antiserum and then assayed for NF-KB activation by HVS13. Preincubation with the IL-1 7R antiserum dramatically decreased the NF-KB activity induced by HVSl3 as compared with cells preincubated with an irrelevant rat antiserum (Figure 5C). This result indicated that the engagement of the IL-17R by its ligands induced NF-KB activity. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Multiple sclerosis |
| + |
NfKb-p65/p50 | down-regulates quantity by repression
transcriptional regulation
|
BHMT |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254659 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16953798 |
SAM and MTA down-regulate BHMT expression in HepG2 cells in part by inducing NF-kappaB, which acts as a repressor for the human BHMT gene. While SAM's mechanism is NF-kappaB-dependent, MTA has both NF-kappaB-dependent and -independent mechanisms. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NfKb-p65/p50 | up-regulates
binding
|
SP1 |
0.56 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-216334 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10671503 |
Rela (p65) nf-kappab subunit interacts with the zinc finger dna-binding domain of sp1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, miRNA in AML |
| + |
NfKb-p65/p50 | up-regulates quantity by expression
transcriptional regulation
|
IL1RN |
0.328 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254794 |
|
|
Homo sapiens |
Neutrophil, Monocyte |
| pmid |
sentence |
| 20032313 |
The interleukin 1 receptor antagonist (IL-1ra) is an important negative regulator of the inflammatory response, whose genetic deficiency has been recently shown to cause a severe autoinflammatory syndrome in humans. In this study we characterized the molecular mechanisms whereby interleukin 10 (IL-10) potentiates IL-1ra transcription in LPS-stimulated monocytes and neutrophils. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | IL1 Signaling , SARS-CoV CYTOKINE STORM |
| + |
NfKb-p65/p50 | up-regulates
|
Interferon_Production |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-216322 |
|
|
Mus musculus |
MEF Cell |
| pmid |
sentence |
| 20610653 |
Type 1 IFNs are induced in a cell type-specific manner through Toll-like receptor and RIG-I-like receptor pathways, both of which activate interferon regulatory factors (IRFs) and nuclear factor _B (NF-_B) transcription factors. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | B-cell activation, EBV infection, Toll like receptors |
| + |
NfKb-p65/p50 | up-regulates quantity by expression
transcriptional regulation
|
MMP13 |
0.305 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254800 |
|
|
Homo sapiens |
Chondrocyte Cell Line |
| pmid |
sentence |
| 12734180 |
The suppressive effect of IGF-1 and OP-1 on MMP-13 expression was due in part to down-regulation of the expression of pro-inflammatory cytokines and the activity of their intermediate molecules, including NF-kappaB and AP-1 factors. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TNFRSF11A | up-regulates activity
|
NfKb-p65/p50 |
0.258 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253047 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10075662 |
RANK activates NF-κB by interacting with TRAF6 via a novel TRAF6 interaction motif and TRAF6 potentially activates NIK, leading to NF-κB activation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TSC22D3 | down-regulates activity
binding
|
NfKb-p65/p50 |
0.35 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253299 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 11468175 |
GILZ inhibits NF-kappaB nuclear translocation and DNA binding due to a direct protein-to-protein interaction of GILZ with the NF-kappaB subunits. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NfKb-p65/p50 | up-regulates quantity by expression
transcriptional regulation
|
CD80 |
0.295 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254783 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12860928 |
Upon CD40 signaling, transcription of the CD80 gene is induced by the nuclear factor (NF)-kappaB transcription factor. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NfKb-p65/p50 | up-regulates
|
Inflammation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260445 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24168260 |
NF-κB, which can be activated by mitogen-activated protein kinases (MAPKs) (12), is responsible for the transcription of inflammatory factors and profibrotic cytokines, which promote an inflammatory response and fibrosis |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-245039 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20457564 |
The nuclear factor NF-kappaB pathway has long been considered a prototypical proinflammatory signaling pathway, largely based on the role of NF-kappaB in the expression of proinflammatory genes including cytokines, chemokines, and adhesion molecules. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255489 |
|
|
|
|
| pmid |
sentence |
| 25309941 |
Following GSK3β activation, NF-κB is translocated from the cytoplasm to the nucleus and binds transcriptional sites with CBP leading to an increase in the transcription of pro-inflammatory cytokines (IL-1β, TNF-α, and IL-6). |
|
| Publications: |
3 |
Organism: |
Homo Sapiens, |
| Pathways: | B-cell activation, COVID-19 Causal Network, EBV infection, Fibrosis, Glucocorticoid receptor Signaling, Innate Immune Response, IL1 Signaling , Inflammosome Activation, Multiple sclerosis, NF-KB Canonical, Pancreatic ductal adenocarcinoma (PDA), SARS-CoV CYTOKINE STORM, SARS-CoV FIBROSIS, SARS-CoV INFLAMMATORY RESPONSE, SARS-CoV INNATE RESPONSE TO dsRNA, TNF-alpha Signaling |
| + |
IKBKB |
Fatal error: Uncaught TypeError: implode(): Argument #2 ($array) must be of type ?array, string given in /home/prisca/signor/relation_result.php:2084
Stack trace:
#0 /home/prisca/signor/relation_result.php(2084): implode()
#1 {main}
thrown in /home/prisca/signor/relation_result.php on line 2084
4.0
NfKb-p65/p50
CPX-5828