Relation Results

Summary

Name AKR1C4
Full Name Aldo-keto reductase family 1 member C4
Synonyms 3-alpha-HSD1, 3-alpha-hydroxysteroid dehydrogenase type I, 1.1.1.357, Chlordecone reductase, CDR, 1.1.1.225, Dihydrodiol dehydrogenase 4, DD-4, DD4, HAKRA | CHDR
Primary ID P17516
Links - -
Type protein
Relations 4
Function Cytosolic aldo-keto reductase that catalyzes the NADH and NADPH-dependent reduction of ketosteroids to hydroxysteroids. Liver specific enzyme that act ...
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Type: Score: Layout: SPV 
0.20.2560.2460.2HNF4GAKR1C4HNF4AHNF1AHNF1B

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Relations
Regulator
Mechanism
target
score ℹ
+ HNF4Gup-regulates quantity by expression img/indirect-activation.png transcriptional regulation AKR1C4 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-240013 Homo sapiens ACHN Cell
pmid sentence
Hepatocyte nuclear factor (HNF)-4_/_, HNF-1_, and vHNF-1 regulate the cell-specific expression of the human dihydrodiol dehydrogenase (DD)4/AKR1C4 gene. HNF-4_ is a necessary factor for the activation of the human DD4 gene. is much higher than that of vHNF-1-C.
Publications: 1 Organism: Homo Sapiens
+ HNF4Aup-regulates quantity by expression img/indirect-activation.png transcriptional regulation AKR1C4 0.256
Identifier Residue Sequence Organism Cell Line
SIGNOR-240016 Homo sapiens ACHN Cell
pmid sentence
Hepatocyte nuclear factor (HNF)-4_/_, HNF-1_, and vHNF-1 regulate the cell-specific expression of the human dihydrodiol dehydrogenase (DD)4/AKR1C4 gene. HNF-4_ is a necessary factor for the activation of the human DD4 gene. is much higher than that of vHNF-1-C.
Publications: 1 Organism: Homo Sapiens
+ HNF1Aup-regulates quantity by expression img/indirect-activation.png transcriptional regulation AKR1C4 0.246
Identifier Residue Sequence Organism Cell Line
SIGNOR-239964 Homo sapiens
pmid sentence
Hepatocyte nuclear factor (HNF)-4_/_, HNF-1_, and vHNF-1 regulate the cell-specific expression of the human dihydrodiol dehydrogenase (DD)4/AKR1C4 gene. HNF-1_ binds to the target element in the rat DBP gene in the liver, while vHNF-1 recognizes a target element in extrahepatic tissues. The ability of vHNF-1-A to activate the rat DBP gene is much higher than that of vHNF-1-C.
Publications: 1 Organism: Homo Sapiens
+ HNF1Bup-regulates quantity by expression img/indirect-activation.png transcriptional regulation AKR1C4 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-239960 Homo sapiens ACHN Cell
pmid sentence
Hepatocyte nuclear factor (HNF)-4_/_, HNF-1_, and vHNF-1 regulate the cell-specific expression of the human dihydrodiol dehydrogenase (DD)4/AKR1C4 gene.HNF-1_ binds to the target element in the rat DBP gene in the liver, while vHNF-1 recognizes a target element in extrahepatic tissues. The ability of vHNF-1-A to activate the rat DBP gene is much higher than that of vHNF-1-C.
Publications: 1 Organism: Homo Sapiens
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