| + |
HNF1B | up-regulates quantity by expression 
transcriptional regulation
|
AKR1C4 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-239960 |
|
|
Homo sapiens |
ACHN Cell |
| pmid |
sentence |
| 2044952 |
Hepatocyte nuclear factor (HNF)-4_/_, HNF-1_, and vHNF-1 regulate the cell-specific expression of the human dihydrodiol dehydrogenase (DD)4/AKR1C4 gene.HNF-1_ binds to the target element in the rat DBP gene in the liver, while vHNF-1 recognizes a target element in extrahepatic tissues. The ability of vHNF-1-A to activate the rat DBP gene is much higher than that of vHNF-1-C. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PCBD1 | up-regulates activity 
binding
|
HNF1B |
0.6 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254910 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24204001 |
Overexpression in a human kidney cell line showed that wild-type PCBD1 binds HNF1B to costimulate the FXYD2 promoter, the activity of which is instrumental in Mg(2+) reabsorption in the DCT. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Renal Distal Tubule |
| + |
HNF1B | up-regulates quantity by expression
transcriptional regulation
|
AFP |
0.327 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254638 |
|
|
Homo sapiens |
Hep-G2 Cell |
| pmid |
sentence |
| 7549116 |
HNF-1 beta was found to be more potent than HNF-1 alpha in activating the AFP promoter in the HepG2 cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HNF1B | up-regulates quantity by expression
transcriptional regulation
|
FXYD2 |
0.3 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254909 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24204001 |
Overexpression in a human kidney cell line showed that wild-type PCBD1 binds HNF1B to costimulate the FXYD2 promoter, the activity of which is instrumental in Mg(2+) reabsorption in the DCT. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251927 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19389850 |
We analyzed genes associated with hypermagnesuria and detected highly conserved HNF1 recognition sites in FXYD2, a gene that can cause autosomal dominant hypomagnesemia and hypocalciuria when mutated. Using a luciferase reporter assay, we demonstrated HNF1B-mediated transactivation of FXYD2. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Tissue: |
Renal Distal Tubule |
| + |
HNF1B | up-regulates activity
binding
|
ATF1 |
0.31 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-241320 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 9671480 |
The mammalian two-hybrid system showed that the region aa 393 to 476 of LFB3 is involved in the interaction with CREB or ATF1. The importance of this region for mediating cAMP induction was confirmed in transient transfection assays. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HNF1B | up-regulates quantity by expression
transcriptional regulation
|
UMOD |
0.379 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254441 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18846391 |
UMOD transcription is activated by the transcription factor HNF1B. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HNF1B | up-regulates activity
binding
|
CREB1 |
0.381 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-241323 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 9671480 |
The mammalian two-hybrid system showed that the region aa 393 to 476 of LFB3 is involved in the interaction with CREB or ATF1. The importance of this region for mediating cAMP induction was confirmed in transient transfection assays. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HNF1B | up-regulates quantity by expression
transcriptional regulation
|
ALB |
0.3 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251930 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 1673926 |
VHNF1 transactivated the albumin promoter in transfection experiments |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
HNF1B
- 
- 