3.0
Summary
| Name |  PFKLView Modifications |
| Full Name | ATP-dependent 6-phosphofructokinase, liver type |
| Synonyms | ATP-PFK, PFK-L, 6-phosphofructokinase type B, Phosphofructo-1-kinase isozyme B, PFK-B, Phosphohexokinase | |
| Primary ID | P17858 |
| Links |  -  -  |
| Type | protein |
| Relations | 6 |
| Function | Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis (PubMed:22923583). Negatively regulates the phagocyte oxidative burst in response to bacterial infection by controlling cellular NADPH biosynthesis and NADPH oxidase-derived reactive oxygen species. Upon macrophage activation, drives the metabolic switch toward glycolysis, thus preventing glucose turnover that produces NADPH via pentose phosphate pathway (By similarity). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | OGA | up-regulates activity 
deglycosylation
|
PFKL | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | OGT | down-regulates activity 
glycosylation
|
PFKL | 0.282 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PFKL | down-regulates quantity
chemical modification
|
β-D-fructose 6-phosphate | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Glycolysis and Gluconeogenesis | |||
| + | PFKL | up-regulates quantity
chemical modification
|
beta-D-fructofuranose 1,6-bisphosphate(4-) | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Glycolysis and Gluconeogenesis | |||
| + | CyclinD3/CDK6 | down-regulates activity
phosphorylation
|
PFKL | 0.2 |
| Publications: | 1 | Organism: | In Vitro | |
| + | beta-D-fructofuranose 2,6-bisphosphate | up-regulates activity
binding
|
PFKL | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Glycolysis and Gluconeogenesis | |||