3.0
Summary
| Name |  GABRG2View Modifications |
| Full Name | Gamma-aminobutyric acid receptor subunit gamma-2 |
| Synonyms | GABA(A) receptor subunit gamma-2 | |
| Primary ID | P18507 |
| Links |  -  -  |
| Type | protein |
| Relations | 7 |
| Function | Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain (PubMed:2538761, PubMed:29950725). Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel (PubMed:23909897, PubMed:25489750, PubMed:27864268). The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer (By similarity). The alpha1/beta2/gamma2 receptor and the alpha1/beta3/gamma2 receptor exhibit synaptogenic activity (PubMed:23909897, PubMed:25489750). The alpha2/beta2/gamma2 receptor exhibits synatogenic activity whereas the alpha2/beta3/gamma2 receptor shows very little or no synaptogenic activity (By similarity). Functions also as histamine receptor and mediates cellular responses to histamine (By similarity). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | PRKCE | down-regulates activity 
phosphorylation
|
GABRG2 | 0.235 |
| Publications: | 1 | Organism: | In Vitro | |
| + | GABRG2 | form complex 
binding
|
GABA-A (a5-b1-g2) receptor | 0.634 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Tissue: | Central Nervous System | |||
| + | GABRG2 | form complex
binding
|
GABA-A (a6-b1-g2) receptor | 0.625 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Tissue: | Central Nervous System | |||
| + | GABRG2 | form complex
binding
|
GABA-A (a2-b1-g2) receptor | 0.622 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Tissue: | Central Nervous System | |||
| + | GABRG2 | form complex
binding
|
GABA-A (a3-b1-g2) receptor | 0.62 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Tissue: | Central Nervous System | |||
| + | GABRG2 | form complex
binding
|
GABA-A (a1-b1-g2) receptor | 0.641 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Tissue: | Central Nervous System | |||
| + | GABRG2 | form complex
binding
|
GABA-A (a4-b1-g2) receptor | 0.625 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Tissue: | Central Nervous System | |||