| + |
flumazenil | up-regulates activity 
chemical activation
|
GABA-A (a4-b1-g2) receptor |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263807 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18790874 |
Receptors containing the alpha4 or alpha6 subunits, together with beta and gamma2, do not bind the traditional BZ agonists, including zolpidem, but demonstrate high affinity for some ligands, notably the imidazobenzodiazepines such as flumazenil and Ro15-4513, or bretazenil |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Central Nervous System |
| + |
GABRG2 | form complex 
binding
|
GABA-A (a4-b1-g2) receptor |
0.625 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263761 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18790874 |
The assembly of GABAA-R as heteropentamers produces complex subtype heterogeneity in structure, which is the major determinant of their pharmacological profile.|Evidence is greatly in favor of a pentameric receptor and most GABAA-R subtypes are formed from two copies of a single alpha, two copies of a single beta, and one copy of another subunit, such as gamma, delta, or epsilon. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Central Nervous System |
| + |
Oxytocin | up-regulates 
|
GABA-A (a4-b1-g2) receptor |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268582 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 33536967 |
OT inhibits corticotropin-releasing factor (CRF) mRNA expression at the hypothalamus, resulting in antistress and anti-anxiety effects| It has been demonstrated that the inhibitory effect of OT on CRF mRNA expression is not a direct one on CRF neurons. GABAergic neurons are present in the surroundings of the PVN (peri-PVN). These GABA-projecting neurons into the PVN inhibits CRF expression via GABAA receptors |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
hydrogencarbonate | up-regulates activity
chemical activation
|
GABA-A (a4-b1-g2) receptor |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264923 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 26136660 |
The raise in the intracellular bicarbonate concentration may augment the depolarizing efflux of bicarbonate upon activation of GABAA receptors; however, both transporters also extrude chloride and thereby increase the gradient for a hyperpolarizing chloride current. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
gamma-aminobutyric acid | up-regulates activity
chemical activation
|
GABA-A (a4-b1-g2) receptor |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263789 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18790874 |
Gamma-Aminobutyric acid (GABA1), the major inhibitory neurotransmitter in the brain, exerts its action via ionotropic GABAA and metabotropic GABAB receptors. GABAA receptors (GABAA-Rs) are the major inhibitory receptors in the central nervous system (CNS). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | GABAergic synapse |
| + |
GABA-A (a4-b1-g2) receptor | up-regulates quantity
relocalization
|
chloride |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263813 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18790874 |
GABAA receptors (GABAA-Rs) are the major inhibitory receptors in the central nervous system (CNS). |Mammalian GABAA-Rs are all anion-selective channels. Increased chloride permeability generally reduces neuronal excitability (inhibition) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | GABAergic synapse |
| + |
GABRB1 | form complex
binding
|
GABA-A (a4-b1-g2) receptor |
0.604 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263760 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18790874 |
The assembly of GABAA-R as heteropentamers produces complex subtype heterogeneity in structure, which is the major determinant of their pharmacological profile.|Evidence is greatly in favor of a pentameric receptor and most GABAA-R subtypes are formed from two copies of a single alpha, two copies of a single beta, and one copy of another subunit, such as gamma, delta, or epsilon. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GABRA4 | form complex
binding
|
GABA-A (a4-b1-g2) receptor |
0.598 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263759 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18790874 |
The assembly of GABAA-R as heteropentamers produces complex subtype heterogeneity in structure, which is the major determinant of their pharmacological profile.|Evidence is greatly in favor of a pentameric receptor and most GABAA-R subtypes are formed from two copies of a single alpha, two copies of a single beta, and one copy of another subunit, such as gamma, delta, or epsilon. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Central Nervous System |
| + |
GABA-A (a4-b1-g2) receptor | down-regulates 
|
CRHR2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268592 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 33536967 |
OT inhibits corticotropin-releasing factor (CRF) mRNA expression at the hypothalamus, resulting in antistress and anti-anxiety effects| It has been demonstrated that the inhibitory effect of OT on CRF mRNA expression is not a direct one on CRF neurons. GABAergic neurons are present in the surroundings of the PVN (peri-PVN). These GABA-projecting neurons into the PVN inhibits CRF expression via GABAA receptors |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Hypothalamus |
| + |
GABA-A (a4-b1-g2) receptor | down-regulates
|
CRHR1 |
0.242 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268603 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 33536967 |
OT inhibits corticotropin-releasing factor (CRF) mRNA expression at the hypothalamus, resulting in antistress and anti-anxiety effects| It has been demonstrated that the inhibitory effect of OT on CRF mRNA expression is not a direct one on CRF neurons. GABAergic neurons are present in the surroundings of the PVN (peri-PVN). These GABA-projecting neurons into the PVN inhibits CRF expression via GABAA receptors |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Hypothalamus |
| + |
DGC | up-regulates quantity
binding
|
GABA-A (a4-b1-g2) receptor |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265435 |
|
|
Homo sapiens |
Neuron, Glial Cell |
| pmid |
sentence |
| 22626542 |
In brain, the DGC is involved in the organisation of GABA(A) receptors (GABA(A)Rs) and aquaporin-4 (AQP4)-containing protein complexes in neurons and glia, respectively. DGC-like complexes function in the postsynaptic clustering and stabilisation of GABAARs in a subset of inhibitory GABAergic synapses. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GABA-A (a4-b1-g2) receptor | down-regulates
|
Excitatory_synaptic_transmission |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263779 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18790874 |
GABAA receptors (GABAA-Rs) are the major inhibitory receptors in the central nervous system (CNS). |Mammalian GABAA-Rs are all anion-selective channels. Increased chloride permeability generally reduces neuronal excitability (inhibition) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Central Nervous System |
| Pathways: | GABAergic synapse |
3.0
GABA-A (a4-b1-g2) receptor