Relation Results

Summary

Name RCC1
Full Name Regulator of chromosome condensation
Synonyms Cell cycle regulatory protein, Chromosome condensation protein 1 | CHC1
Primary ID P18754
Links - -
Type protein
Relations 6
Function Guanine-nucleotide releasing factor that promotes the exchange of Ran-bound GDP by GTP, and thereby plays an important role in RAN-mediated functions ...
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Type: Score: Layout: SPV 
0.20.517STK3RCC1CDK1

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ STK3up-regulates img/direct-activation.png phosphorylation RCC1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-263145 Ser11 KRIAKRRsPPADAIP Homo sapiens HEK-293 Cell
pmid sentence
MST2 Phosphorylates RCC1 In Vitro and In Vivo. Using an antibody generated against phospho-S2/11 in RCC1 [18], we found that these two residues were also efficiently phosphorylated by MST1 and MST2 (Figure 2D), further supporting that S2 and/or S11 are genuine MST2 phosphorylation targets.
Identifier Residue Sequence Organism Cell Line
SIGNOR-263146 Ser2 sPKRIAKR Homo sapiens HEK-293 Cell
pmid sentence
MST2 Phosphorylates RCC1 In Vitro and In Vivo. Using an antibody generated against phospho-S2/11 in RCC1 [18], we found that these two residues were also efficiently phosphorylated by MST1 and MST2 (Figure 2D), further supporting that S2 and/or S11 are genuine MST2 phosphorylation targets.
Publications: 2 Organism: Homo Sapiens
+ CDK1up-regulates activity img/direct-activation.png phosphorylation RCC1 0.517
Identifier Residue Sequence Organism Cell Line
SIGNOR-262702 Ser11 KRIAKRRsPPADAIP in vitro
pmid sentence
Human RCC1 is phosphorylated on Ser 2 and Ser 11 in mitosis by Cdc2 kinase. We show here that Cdc2 kinase phosphorylates the serines located in or near the nuclear localization signal (NLS) of human RCC1, the nucleotide exchange factor for Ran. This phosphorylation is necessary for RCC1 to generate RanGTP on mitotic chromosomes in mammalian cells, which in turn is required for spindle assembly and chromosome segregation.
Identifier Residue Sequence Organism Cell Line
SIGNOR-262701 Ser2 sPKRIAKR in vitro
pmid sentence
Human RCC1 is phosphorylated on Ser 2 and Ser 11 in mitosis by Cdc2 kinase. We show here that Cdc2 kinase phosphorylates the serines located in or near the nuclear localization signal (NLS) of human RCC1, the nucleotide exchange factor for Ran. This phosphorylation is necessary for RCC1 to generate RanGTP on mitotic chromosomes in mammalian cells, which in turn is required for spindle assembly and chromosome segregation.
Identifier Residue Sequence Organism Cell Line
SIGNOR-262703 Ser387 GQDEDAWsPVEMMGK in vitro
pmid sentence
We show here that Cdc2 kinase phosphorylates the serines located in or near the nuclear localization signal (NLS) of human RCC1, the nucleotide exchange factor for Ran. This phosphorylation is necessary for RCC1 to generate RanGTP on mitotic chromosomes in mammalian cells, which in turn is required for spindle assembly and chromosome segregation. However, when both S2 and S11 were simultaneously mutated to As, the resulting 6His-RCC1S2,11A failed to be phosphorylated, whereas all of the other double mutants were phosphorylated (Fig. 1C). As expected, mutating all four sites to As (the 6His-RCC1S2,11,387A-T274A) also blocked phosphorylation (Fig. 1C).
Identifier Residue Sequence Organism Cell Line
SIGNOR-262704 Thr274 SNYHQLGtPGTESCF in vitro
pmid sentence
We show here that Cdc2 kinase phosphorylates the serines located in or near the nuclear localization signal (NLS) of hum an RCC1, the nucleotide exchange factor for Ran. This phosphorylation is necessary for RCC1 to generate RanGTP on mitotic chromosomes in mammalian cells, which in turn is required for spindle assembly and chromosome segregation. However, when both S2 and S11 were simultaneously mutated to As, the resulting 6His-RCC1S2,11A failed to be phosphorylated, whereas all of the other double mutants were phosphorylated (Fig. 1C). As expected, mutating all four sites to As (the 6His-RCC1S2,11,387A-T274A) also blocked phosphorylation (Fig. 1C).
Publications: 4 Organism: In Vitro
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