| + |
STK3 | up-regulates 
phosphorylation
|
RCC1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263145 |
Ser11 |
KRIAKRRsPPADAIP |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 19559616 |
MST2 Phosphorylates RCC1 In Vitro and In Vivo. Using an antibody generated against phospho-S2/11 in RCC1 [18], we found that these two residues were also efficiently phosphorylated by MST1 and MST2 (Figure 2D), further supporting that S2 and/or S11 are genuine MST2 phosphorylation targets. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263146 |
Ser2 |
sPKRIAKR |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 19559616 |
MST2 Phosphorylates RCC1 In Vitro and In Vivo. Using an antibody generated against phospho-S2/11 in RCC1 [18], we found that these two residues were also efficiently phosphorylated by MST1 and MST2 (Figure 2D), further supporting that S2 and/or S11 are genuine MST2 phosphorylation targets. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
PLK1 | down-regulates activity 
phosphorylation
|
STK3 |
0.337 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277904 |
Ser15 |
KSKLKKLsEDSLTKQ |
Homo sapiens |
HEK-293T Cell |
| pmid |
sentence |
| 37739411 |
We conclude that TRIM69A promotes multi-site phosphorylation of MST2.We demonstrate that TRIM69 stimulates formation of an MST2-PLK1 complex and promotes phosphorylation of MST2 at S15, a known PLK1 site. PLK1-mediated MST2 phosphorylation at S15 is necessary for subsequent phosphorylation of NEK2A to dissociate c-NAP1 from daughter centrioles (7). Thus, we provide a new molecular mechanism by which TRIM69 promotes MST2- and PLK1-mediated centrosome disjunction. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
STK3 | up-regulates activity
phosphorylation
|
PRKCA |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277177 |
Ser226 |
LNPQWNEsFTFKLKP |
Homo sapiens |
HEK-293T Cell |
| pmid |
sentence |
| 26414765 |
Thus, the phosphorylation of PKCα at Ser226 and Thr228 by Mst1 and Mst2 is required for the optimal activation of PKCα. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277176 |
Thr228 |
PQWNESFtFKLKPSD |
Homo sapiens |
HEK-293T Cell |
| pmid |
sentence |
| 26414765 |
Thus, the phosphorylation of PKCα at Ser226 and Thr228 by Mst1 and Mst2 is required for the optimal activation of PKCα. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
STK3 | up-regulates
phosphorylation
|
NEK2 |
0.245 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-169539 |
Ser438 |
EKNYQLKsRQILGMR |
Homo sapiens |
|
| pmid |
sentence |
| 21076410 |
Our data suggest that mst2 phosphorylates nek2a thereby recruiting nek2a to centrosomes and promoting phosphorylation and displacement of centrosomal linker proteins |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
STK3 | up-regulates
phosphorylation
|
LATS2 |
0.594 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-201274 |
Ser872 |
HQRCLAHsLVGTPNY |
Homo sapiens |
|
| pmid |
sentence |
| 23431053 |
MST1/2 directly phosphorylate Lats1/2 at the hydrophobic motif (Lats1 T1079 and Lats2 T1041), and this phosphorylation is required for Lats1/2 activation |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-175797 |
Ser872 |
HQRCLAHsLVGTPNY |
Homo sapiens |
|
| pmid |
sentence |
| 21808241 |
Activation of mst1/2 leads to phosphorylation and activation of their direct substrates, lats1/2. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-201278 |
Thr1041 |
EHAFYEFtFRRFFDD |
Homo sapiens |
|
| pmid |
sentence |
| 23431053 |
MST1/2 directly phosphorylate Lats1/2 at the hydrophobic motif (Lats1 T1079 and Lats2 T1041), and this phosphorylation is required for Lats1/2 activation |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-175801 |
Thr1041 |
EHAFYEFtFRRFFDD |
Homo sapiens |
|
| pmid |
sentence |
| 21808241 |
Activation of mst1/2 leads to phosphorylation and activation of their direct substrates, lats1/2. |
|
| Publications: |
4 |
Organism: |
Homo Sapiens |
| Pathways: | Hippo Signaling |
| + |
STK3 | up-regulates
phosphorylation
|
LATS1 |
0.605 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-133544 |
Ser909 |
HQRCLAHsLVGTPNY |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 15688006 |
Since the N-terminal half of Lats1 (residues 1588) was dispensable for the activation of Lats1 by Mst2, mass spectrometry was used to identify phosphorylation sites within the C-terminal domain of Lats1. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-132927 |
Thr1079 |
EHAFYEFtFRRFFDD |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 15688006 |
Since the N-terminal half of Lats1 (residues 1588) was dispensable for the activation of Lats1 by Mst2, mass spectrometry was used to identify phosphorylation sites within the C-terminal domain of Lats1. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | Hippo Signaling |
| + |
STK3 | down-regulates activity
phosphorylation
|
PIK3CA |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277922 |
Thr1061 |
KMDWIFHtIKQHALN |
in vitro |
|
| pmid |
sentence |
| 38060450 |
MST1/2 and HGK inhibit catalytic activity of p110α through phosphorylation at T1061 |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
AKT | down-regulates
phosphorylation
|
STK3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-244345 |
Thr117 |
IIRLRNKtLIEDEIA |
Homo sapiens |
|
| pmid |
sentence |
| 20086174 |
We determined that mst2 phosphorylation by akt limits mst2 activity in two ways: first, by blocking its binding to rassf1a and by promoting its association into the raf-1 inhibitory complex, and second, by preventing homodimerization of mst2, which is needed for its activation. we identified t117 and t384 as akt phosphorylation sites in mst2. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-164298 |
Thr117 |
IIRLRNKtLIEDEIA |
Homo sapiens |
Breast Cancer Cell |
| pmid |
sentence |
| 20231902 |
Akt phosphorylates mst2 at thr117 in vitro and in vivo, which leads to mst2 cleavage and kinase activity as well as nuclear translocation. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-244349 |
Thr384 |
GTMKRNAtSPQVQRP |
Homo sapiens |
|
| pmid |
sentence |
| 20086174 |
We determined that mst2 phosphorylation by akt limits mst2 activity in two ways: first, by blocking its binding to rassf1a and by promoting its association into the raf-1 inhibitory complex, and second, by preventing homodimerization of mst2, which is needed for its activation. we identified t117 and t384 as akt phosphorylation sites in mst2. |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| + |
AKT1 | down-regulates
phosphorylation
|
STK3 |
0.363 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252509 |
Thr117 |
IIRLRNKtLIEDEIA |
Homo sapiens |
Breast Cancer Cell |
| pmid |
sentence |
| 20231902 |
Akt phosphorylates mst2 at thr117 in vitro and in vivo, which leads to mst2 cleavage and kinase activity as well as nuclear translocation. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-163533 |
Thr117 |
IIRLRNKtLIEDEIA |
Homo sapiens |
|
| pmid |
sentence |
| 20086174 |
We determined that mst2 phosphorylation by akt limits mst2 activity in two ways: first, by blocking its binding to rassf1a and by promoting its association into the raf-1 inhibitory complex, and second, by preventing homodimerization of mst2, which is needed for its activation. we identified t117 and t384 as akt phosphorylation sites in mst2. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-163537 |
Thr384 |
GTMKRNAtSPQVQRP |
Homo sapiens |
|
| pmid |
sentence |
| 20086174 |
We determined that mst2 phosphorylation by akt limits mst2 activity in two ways: first, by blocking its binding to rassf1a and by promoting its association into the raf-1 inhibitory complex, and second, by preventing homodimerization of mst2, which is needed for its activation. we identified t117 and t384 as akt phosphorylation sites in mst2. |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| + |
AKT3 | down-regulates
phosphorylation
|
STK3 |
0.274 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-164306 |
Thr117 |
IIRLRNKtLIEDEIA |
Homo sapiens |
Breast Cancer Cell |
| pmid |
sentence |
| 20231902 |
Akt phosphorylates mst2 at thr117 in vitro and in vivo, which leads to mst2 cleavage and kinase activity as well as nuclear translocation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
AKT2 | down-regulates
phosphorylation
|
STK3 |
0.263 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-164302 |
Thr117 |
IIRLRNKtLIEDEIA |
Homo sapiens |
Breast Cancer Cell |
| pmid |
sentence |
| 20231902 |
Akt phosphorylates mst2 at thr117 in vitro and in vivo, which leads to mst2 cleavage and kinase activity as well as nuclear translocation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
STK3 | up-regulates
phosphorylation
|
MOB1B |
0.81 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-201290 |
Thr12 |
FGSRSSKtFKPKKNI |
Homo sapiens |
|
| pmid |
sentence |
| 23431053 |
Mob1, when phosphorylated by MST1/2, binds to the autoinhibitory motif in Lats1/2, which in turn leads to the phosphorylation of the Lats activation loop (Lats1 S909 and Lats2 S872) and thereby an increase of their kinase activity |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-175813 |
Thr12 |
FGSRSSKtFKPKKNI |
Homo sapiens |
|
| pmid |
sentence |
| 21808241 |
Mob1, which forms a complex with lats1/2, is also phosphorylated by mst1/2, resulting in an enhanced lats1/2 mob1 interaction. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-201294 |
Thr35 |
LLKHAEAtLGSGNLR |
Homo sapiens |
|
| pmid |
sentence |
| 23431053 |
Mob1, when phosphorylated by MST1/2, binds to the autoinhibitory motif in Lats1/2, which in turn leads to the phosphorylation of the Lats activation loop (Lats1 S909 and Lats2 S872) and thereby an increase of their kinase activity |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-175817 |
Thr35 |
LLKHAEAtLGSGNLR |
Homo sapiens |
|
| pmid |
sentence |
| 21808241 |
Mob1, which forms a complex with lats1/2, is also phosphorylated by mst1/2, resulting in an enhanced lats1/2 mob1 interaction. |
|
| Publications: |
4 |
Organism: |
Homo Sapiens |
| Pathways: | Hippo Signaling |
| + |
STK3 | up-regulates
phosphorylation
|
MOB1A |
0.846 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-175805 |
Thr12 |
FSSRSSKtFKPKKNI |
Homo sapiens |
|
| pmid |
sentence |
| 21808241 |
Mob1, which forms a complex with lats1/2, is also phosphorylated by mst1/2, resulting in an enhanced lats1/2 mob1 interaction. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-201282 |
Thr12 |
FSSRSSKtFKPKKNI |
Homo sapiens |
|
| pmid |
sentence |
| 23431053 |
Mob1, when phosphorylated by MST1/2, binds to the autoinhibitory motif in Lats1/2, which in turn leads to the phosphorylation of the Lats activation loop (Lats1 S909 and Lats2 S872) and thereby an increase of their kinase activity |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-175809 |
Thr35 |
LLKHAEAtLGSGNLR |
Homo sapiens |
|
| pmid |
sentence |
| 21808241 |
Mob1, which forms a complex with lats1/2, is also phosphorylated by mst1/2, resulting in an enhanced lats1/2 mob1 interaction. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-201286 |
Thr35 |
LLKHAEAtLGSGNLR |
Homo sapiens |
|
| pmid |
sentence |
| 23431053 |
Mob1, when phosphorylated by MST1/2, binds to the autoinhibitory motif in Lats1/2, which in turn leads to the phosphorylation of the Lats activation loop (Lats1 S909 and Lats2 S872) and thereby an increase of their kinase activity |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-177977 |
Thr74 |
QINMLYGtITEFCTE |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 18362890 |
These findings indicate that the phosphorylation of mob1 at thr74 by mst2 is essential to make a complex of mob1, mst2 and ndr1, and to fully activate ndr1 |
|
| Publications: |
5 |
Organism: |
Homo Sapiens |
| Pathways: | Hippo Signaling |
| + |
STK3 | up-regulates
phosphorylation
|
STK3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-164310 |
Thr180 |
DTMAKRNtVIGTPFW |
Homo sapiens |
Breast Cancer Cell |
| pmid |
sentence |
| 20231902 |
Consistent with previous studies, sts alone induces mst2 cleavage and autophosphorylation of thr180, an indicator of mst2 activation, as well as apoptosis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Hippo Signaling |
| + |
PPP2CA | down-regulates
dephosphorylation
|
STK3 |
0.685 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-201266 |
Thr180 |
DTMAKRNtVIGTPFW |
Homo sapiens |
|
| pmid |
sentence |
| 23431053 |
Rassf1a apparently protects mst1/2 against inactivation by pp2a, the phosphatases that dephosphorylate the stimulatory thr-183 and thr-180 of mst1 andmst2, respectively. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
STK3 | down-regulates activity
phosphorylation
|
STAT3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277599 |
Thr622 |
KEGGVTFtWVEKDIS |
in vitro |
|
| pmid |
sentence |
| 35722967 |
Hippo pathway component MST2 kinase phosphorylates STAT3 at T622, which is located in the SH2 domain of STAT3. This phosphorylation blocks the SH2 domain in one STAT3 molecule to bind with the phosphorylated Y705 site in another STAT3 molecule, which further counteracts IL6-induced STAT3 dimerization and activation. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
STK3 | down-regulates
phosphorylation
|
ABL1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-181056 |
Thr735 |
DTEWRSVtLPRDLQS |
Homo sapiens |
|
| pmid |
sentence |
| 18794806 |
Here, we identify clk1, clk4, mst1, mst2 and ttk (also known as mps1) as novel thr735 kinases in vitro / phosphorylation of thr735 in c-abl is critical for binding to 14-3-3 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ABL1 | up-regulates
phosphorylation
|
STK3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-197538 |
Tyr81 |
MQQCDSPyVVKYYGS |
Homo sapiens |
Neuron |
| pmid |
sentence |
| 22590567 |
We demonstrate that c-abl kinase phosphorylates mst2 at an evolutionarily conserved site, y81, within the kinase domain. We further show that the phosphorylation of mst2 by c-abl leads to the disruption of the interaction with raf-1 proteins and the enhancement of homodimerization of mst2 proteins. It thereby enhances the mst2 activation and induces neuronal cell death. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RAF1 | down-regulates
binding
|
STK3 |
0.367 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-132824 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15618521 |
Raf-1 prevents dimerization and phosphorylation of the activation loop of mst2 independently of its protein kinase activity.Raf-1 counteracts apoptosis by suppressing the activation of mammalian sterile 20-like kinase (mst2) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
WWC1 | up-regulates activity 
|
STK3 |
0.375 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261953 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 20159598 |
These results shed light on the mechanism of Ex and Mer function and implicate Kibra as a potential tumor suppressor with relevance to neurofibromatosis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Hippo Signaling |
| + |
SAV1 | up-regulates quantity by stabilization
binding
|
STK3 |
0.828 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261957 |
|
|
Homo sapiens |
T-REx 293 Cell |
| pmid |
sentence |
| 16930133 |
Association of mammalian sterile twenty kinases, Mst1 and Mst2, with hSalvador via C-terminal coiled-coil domains, leads to its stabilization and phosphorylation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Hippo Signaling |
| + |
okadaic acid | up-regulates
|
STK3 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-201551 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23493077 |
Okadaic acid has been frequently used to enhance the phosphorylation of mst1 and mst2 and to trigger the activation of the hippo pathway. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
STK3 | up-regulates
phosphorylation
|
Mob1 |
0.855 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269855 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21808241 |
Mob1, which forms a complex with lats1/2, is also phosphorylated by mst1/2, resulting in an enhanced lats1/2 mob1 interaction. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Hippo Signaling |
| + |
RASSF6 | down-regulates
binding
|
STK3 |
0.649 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-198463 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22830020 |
When rassf 6 is bound to mst2, rassf 6 inhibits mst2 activity, thus, inhibiting its role in the hippo pathway. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TAOK2 | up-regulates
phosphorylation
|
STK3 |
0.278 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-201327 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23431053 |
In addition, the thousand-and-one (tao) amino acids kinase or taok13 has been shown to directly phosphorylate and activate hpo or mst1/2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TAOK3 | up-regulates
phosphorylation
|
STK3 |
0.295 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-201333 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23431053 |
In addition, the thousand-and-one (tao) amino acids kinase or taok1 3 has been shown to directly phosphorylate and activate hpo or mst1/2 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TAOK1 | up-regulates
phosphorylation
|
STK3 |
0.302 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-201321 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23431053 |
In addition, the thousand-and-one (tao) amino acids kinase or taok13 has been shown to directly phosphorylate and activate hpo or mst1/2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TAOK | up-regulates
phosphorylation
|
STK3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-230713 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23431053 |
In addition, the thousand-and-one (tao) amino acids kinase or taok13 has been shown to directly phosphorylate and activate hpo or mst1/2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Hippo Signaling |
| + |
RASSF1 | up-regulates
binding
|
STK3 |
0.689 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-175790 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21808241 |
Mst1/2 is also activated by binding to Ras association domain family (RASSF) proteins, possibly owing to alteration of Mst1/2 subcellular localization. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Hippo Signaling |
| + |
STK3 | up-regulates
phosphorylation
|
LATS1/2 |
0.605 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269862 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21808241 |
Activation of mst1/2 leads to phosphorylation and activation of their direct substrates, lats1/2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Hippo Signaling |
| + |
STK3 | up-regulates
phosphorylation
|
SAV1 |
0.828 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-230716 |
|
|
in vitro |
HEK-293 Cell |
| pmid |
sentence |
| 16930133 |
In vitro phosphorylation experiments indicate that the phosphorylation of Sav by Mst is direct. The stabilizing effect of Mst was much greater on N-terminally truncated hSav mutants, as long as they retained the ability to bind Mst. Mst mutants that lacked the C-terminal coiled-coil domain and were unable to bind to hSav, also failed to stabilize or phosphorylate hSav |
|
| Publications: |
1 |
Organism: |
In Vitro |
| Pathways: | Hippo Signaling |
| + |
SAV1 | up-regulates
binding
|
STK3 |
0.828 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-169829 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21084559 |
Mst is activated by binding of salvador (sav1, sav in drosophila), which is, in turn, also phosphorylated by mst. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Hippo Signaling |
| + |
RASSF1 | up-regulates activity
binding
|
STK3 |
0.689 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249588 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22195963 |
Mutant K-Ras promotes MST2 activation in two ways (i.e., by direct disruption of the inhibitory Raf-1-MST2 complex (Matallanas et al., 2008) and by forming an activating K-Ras-RASSF1AMST2 complex, as reported here. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Hippo Signaling |
| + |
NF2 | up-regulates activity
binding
|
STK3 |
0.333 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261955 |
|
|
Mus musculus |
Cardiomyocyte Cell Line |
| pmid |
sentence |
| 27402866 |
NF2 is activated by oxidative stress in cardiomyocytes and mouse myocardium and facilitates apoptosis. NF2 promotes I/R injury through activation of Mst1 and inhibition of Yap, thereby regulating Hippo signaling in the adult heart. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Hippo Signaling |
| + |
Cell-Cell_contact | up-regulates
|
STK3 |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-230696 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22683405 |
In response to growth inhibitory signal (e.g. cellcell contact), MST1/2 in active form phosphorylates LATS1/2 that sequentially phosphorylates YAP at Ser-127. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Hippo Signaling |
3.0
STK3
- 
- 