3.0
Summary
| Name |  NCLView Modifications |
| Full Name | Nucleolin |
| Synonyms | Protein C23 |
| Primary ID | P19338 |
| Links |  -  -  |
| Type | protein |
| Relations | 4 |
| Function | Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | PTEN | up-regulates activity 
dephosphorylation
|
NCL | 0.273 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | NCL | down-regulates activity 
binding
|
MYB | 0.41 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | NCL | up-regulates quantity by expression
post transcriptional regulation
|
HBB | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | NCL | down-regulates activity
binding
|
MYBL1 | 0.427 |
| Publications: | 1 | Organism: | Homo Sapiens | |