+ |
SRC | up-regulates activity
phosphorylation
|
NDUFV2 |
0.329 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-276419 |
Tyr193 |
VQINDNYyEDLTAKD |
Homo sapiens |
T-98G Cell |
pmid |
sentence |
22823520 |
Phosphorylation-site analysis selects c-Src targets, including NDUFV2 (NADH dehydrogenase [ubiquinone] flavoprotein 2) at Tyr(193) of respiratory complex I and SDHA (succinate dehydrogenase A) at Tyr(215) of complex II. The phosphorylation of these sites by c-Src is supported by an in vivo assay using cells expressing their phosphorylation-defective mutants. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
SP1 | up-regulates quantity by expression
transcriptional regulation
|
NDUFV2 |
0.352 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-255207 |
|
|
Homo sapiens |
Neuroblastoma Cell |
pmid |
sentence |
17786189 |
Sp1 role in the regulation of complex I subunits, was demonstrated by the ability of the Sp1/DNA binding inhibitor, mithramycin, to inhibit the transcription of NDUFV1 and NDUFV2, in neuroblastoma cells. In addition, Sp1 activated NDUFV2 promoter by binding to its three GC-boxes. Both activation and binding were inhibited by mithramycin. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
NDUFV2 | form complex
binding
|
Mitochondrial respiratory chain complex I |
0.853 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-262184 |
|
|
|
|
pmid |
sentence |
30030361 |
Thus, we now know the complete mammalian cI structure [22,23] and how the subunits are organized in six modules (N, Q, ND1, ND2, ND4 and ND5)The N-module, which is the tip of the hydrophilic arm and the last one to be incorporated [30,35], results from the assembly of NDUFV1, NDUFV2, NDUFS1 and NDUFA2 [34], to which NDUFA6, NDUFA7, NDUFA12, NDUFS4, NDUFS6 and NDUFV3 must be further associated with to complete the module [24]. |
|
Publications: |
1 |