Relation Results

Summary

Name CR2
Full Name Complement receptor type 2
Synonyms Cr2, Complement C3d receptor, Epstein-Barr virus receptor, EBV receptor | C3DR
Primary ID P20023
Links - -
Type protein
Relations 3
Pathways EBV infection
Function Receptor for complement C3, for the Epstein-Barr virus on human B-cells and T-cells and for HNRNPU (PubMed:7753047). Participates in B lymphocytes act ...
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Type: Score: Layout: SPV 
0.20.7840.282BLLF1CR2CD19TCF3

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Relations
Regulator
Mechanism
target
score ℹ
+ BLLF1up-regulates activity img/direct-activation.png binding CR2 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-266624 Homo sapiens B-lymphocyte
pmid sentence
The binding of the Epstein-Barr virus glycoprotein gp350 by complement receptor type 2 (CR2) is critical for viral attachment to B lymphocytes.
Publications: 1 Organism: Homo Sapiens
Pathways:EBV infection
+ CR2up-regulates activity img/direct-activation.png binding CD19 0.784
Identifier Residue Sequence Organism Cell Line
SIGNOR-266642 Homo sapiens B-lymphocyte
pmid sentence
Complement receptor type 2 (CR2)/CD21 plays a key role in the development of high-affinity Abs and long-lasting memory to foreign Ags. When CR2 is bound by its primary C3 activation fragment–derived ligand, designated C3d, it coassociates with CD19 on B cells to amplify BCR signaling.
Publications: 1 Organism: Homo Sapiens
Pathways:EBV infection
+ TCF3down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation CR2 0.282
Identifier Residue Sequence Organism Cell Line
SIGNOR-255387 Homo sapiens
pmid sentence
We have previously described the presence of an intronic element that is required for both cell- and stage-specific expression of CR2. In this study, we report the identification of a cell type-specific repressor element within the proximal promoter. By supershift analysis this element binds members of the basic helix-loop-helix family of proteins, in particular E2A gene products. Mutational analysis demonstrates that binding of E2A proteins is critical for functioning of this repressor. Thus, E2A activity is key not only for early B cell development, but also for controlling CR2 expression, a gene expressed only during later stages of ontogeny.
Publications: 1 Organism: Homo Sapiens
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