| + |
LYN | up-regulates 
phosphorylation
|
CD19 |
0.764 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-80290 |
Tyr500 |
TSLGSQSyEDMRGIL |
Homo sapiens |
|
| pmid |
sentence |
| 10933394 |
Experiments with purified proteins demonstrated that cd19-y513 was lyn's initial phosphorylation and binding site. This led to processive phosphorylation of cd19-y482, which recruited a second lyn molecule, allowing for transphosphorylation and amplification of lyn activation. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-80294 |
Tyr531 |
HEEDADSyENMDNPD |
Homo sapiens |
|
| pmid |
sentence |
| 10933394 |
Experiments with purified proteins demonstrated that cd19-y513 was lyn's initial phosphorylation and binding site. This led to processive phosphorylation of cd19-y482, which recruited a second lyn molecule, allowing for transphosphorylation and amplification of lyn activation. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | B-cell activation, EBV infection |
| + |
LYN | up-regulates activity
phosphorylation
|
CD19 |
0.764 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249376 |
Tyr500 |
TSLGSQSyEDMRGIL |
Mus musculus |
B-lymphocyte |
| pmid |
sentence |
| 10933394 |
Experiments with purified proteins demonstrated that CD19-Y513 was Lyn's initial phosphorylation and binding site. This led to processive phosphorylation of CD19-Y482, which recruited a second Lyn molecule, allowing for transphosphorylation and amplification of Lyn activation|Tyrosine phosphorylation of CD19 following BCR and/or CD19 ligation provides Src homology 2 (SH2) recognition motifs that recruit regulatory molecules to the cell surface. CD19 dually phosphorylated at CD19Y482 and CD19Y513 binds the tandem SH2 domains of phosphatidylinositol 3-kinase (PI 3-kinase) p85 subuni |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249377 |
Tyr531 |
HEEDADSyENMDNPD |
Mus musculus |
B-lymphocyte |
| pmid |
sentence |
| 10933394 |
Experiments with purified proteins demonstrated that CD19-Y513 was Lyn's initial phosphorylation and binding site. This led to processive phosphorylation of CD19-Y482, which recruited a second Lyn molecule, allowing for transphosphorylation and amplification of Lyn activation|Tyrosine phosphorylation of CD19 following BCR and/or CD19 ligation provides Src homology 2 (SH2) recognition motifs that recruit regulatory molecules to the cell surface. CD19 dually phosphorylated at CD19Y482 and CD19Y513 binds the tandem SH2 domains of phosphatidylinositol 3-kinase (PI 3-kinase) p85 subuni |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-242891 |
|
|
Mus musculus |
B-lymphocyte |
| pmid |
sentence |
| 25673924 |
CD19 has an extracellular region containing two C2-type Ig-like domains and a cytoplasmic region of ~240 amino acids with 9 conserved tyrosine residues24. Lyn, a Src-family protein tyrosine kinase member, is the dominant kinase that phosphorylates CD19 upon stimulation. Once tyrosyl-phosphorylated, CD19 serves as a membrane-bound adaptor protein for Src homology 2-containing signaling molecules such as Lyn, Vav, and phosphatidylinositol 3-kinase, which further mediate downstream activation cascades. |
|
| Publications: |
3 |
Organism: |
Mus Musculus |
| Pathways: | B-cell activation, EBV infection |
| + |
ABL1 | up-regulates activity
phosphorylation
|
CD19 |
0.549 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-245283 |
Tyr508 |
EDMRGILyAAPQLRS |
Mus musculus |
|
| pmid |
sentence |
| 11120811 |
The results revealed that only tyrosine (Y)490 of CD19 was phosphorylated by c-Abl. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
CD19 | up-regulates activity
binding
|
PI3K |
0.502 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252669 |
|
|
Mus musculus |
Myeloma Cell Line |
| pmid |
sentence |
| 10201980 |
Phosphorylation of CD19 Y484 and Y515, and linked activation of phosphatidylinositol 3-kinase, are required for B cell antigen receptor-mediated activation of Bruton's tyrosine kinase. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252670 |
|
|
Mus musculus |
B-lymphocyte |
| pmid |
sentence |
| 25673924 |
CD19 has an extracellular region containing two C2-type Ig-like domains and a cytoplasmic region of ~240 amino acids with 9 conserved tyrosine residues24. Lyn, a Src-family protein tyrosine kinase member, is the dominant kinase that phosphorylates CD19 upon stimulation. Once tyrosyl-phosphorylated, CD19 serves as a membrane-bound adaptor protein for Src homology 2-containing signaling molecules such as Lyn, Vav, and phosphatidylinositol 3-kinase, which further mediate downstream activation cascades. |
|
| Publications: |
2 |
Organism: |
Mus Musculus |
| Pathways: | B-cell activation, EBV infection |
| + |
CD19 | up-regulates activity
binding
|
PIK3R1 |
0.567 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-242900 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 25673924 |
CD19 has an extracellular region containing two C2-type Ig-like domains and a cytoplasmic region of ~240 amino acids with 9 conserved tyrosine residues24. Lyn, a Src-family protein tyrosine kinase member, is the dominant kinase that phosphorylates CD19 upon stimulation. Once tyrosyl-phosphorylated, CD19 serves as a membrane-bound adaptor protein for Src homology 2-containing signaling molecules such as Lyn, Vav, and phosphatidylinositol 3-kinase, which further mediate downstream activation cascades. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249608 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 10201980 |
Phosphorylation of CD19 Y484 and Y515, and linked activation of phosphatidylinositol 3-kinase, are required for B cell antigen receptor-mediated activation of Bruton's tyrosine kinase. |
|
| Publications: |
2 |
Organism: |
Mus Musculus |
| + |
CD19 | up-regulates activity
binding
|
LYN |
0.764 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-242894 |
|
|
Mus musculus |
B-lymphocyte |
| pmid |
sentence |
| 25673924 |
CD19 has an extracellular region containing two C2-type Ig-like domains and a cytoplasmic region of ~240 amino acids with 9 conserved tyrosine residues24. Lyn, a Src-family protein tyrosine kinase member, is the dominant kinase that phosphorylates CD19 upon stimulation. Once tyrosyl-phosphorylated, CD19 serves as a membrane-bound adaptor protein for Src homology 2-containing signaling molecules such as Lyn, Vav, and phosphatidylinositol 3-kinase, which further mediate downstream activation cascades. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | B-cell activation, EBV infection |
| + |
CD19 | up-regulates 
|
B_cell_maturation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-242888 |
|
|
Mus musculus |
B-lymphocyte |
| pmid |
sentence |
| 25673924 |
CD19 is a crucial regulator of B cell activation. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | EBV infection |
| + |
blinatumomab | down-regulates activity 
binding
|
CD19 |
0.4 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259888 |
|
|
Homo sapiens |
Acute Lymphoblastic Leukemia Cell |
| pmid |
sentence |
| 25883042 |
Blinatumomab, a bispecific antibody construct targeting CD19, is the most advanced member of bispecific T-cell engager (BiTE®) molecules.Blinatumomab recently gained approval in the United States by the U.S. Food and Drug Administration for treatment of Philadelphia chromosome-negative B-precursor relapsed/refractory acute lymphoblastic leukemia. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CR2 | up-regulates activity
binding
|
CD19 |
0.776 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266642 |
|
|
Homo sapiens |
B-lymphocyte |
| pmid |
sentence |
| 31732528 |
Complement receptor type 2 (CR2)/CD21 plays a key role in the development of high-affinity Abs and long-lasting memory to foreign Ags. When CR2 is bound by its primary C3 activation fragment–derived ligand, designated C3d, it coassociates with CD19 on B cells to amplify BCR signaling. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | EBV infection |
| + |
CD19 | up-regulates activity
|
MAPK1 |
0.398 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249609 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10706702 |
CD19 is a coreceptor on B cells that enhances the increase in cytoplasmic calcium and ERK2 activation when coligated with the B cell Ag receptor. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CD19 | up-regulates activity
binding
|
VAV1 |
0.713 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-242897 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 25673924 |
CD19 has an extracellular region containing two C2-type Ig-like domains and a cytoplasmic region of ~240 amino acids with 9 conserved tyrosine residues24. Lyn, a Src-family protein tyrosine kinase member, is the dominant kinase that phosphorylates CD19 upon stimulation. Once tyrosyl-phosphorylated, CD19 serves as a membrane-bound adaptor protein for Src homology 2-containing signaling molecules such as Lyn, Vav, and phosphatidylinositol 3-kinase, which further mediate downstream activation cascades. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
3.0
CD19
- 
- 