Summary

Name CD33
Full Name Myeloid cell surface antigen CD33
Synonyms Sialic acid-binding Ig-like lectin 3, Siglec-3, gp67 | SIGLEC3
Primary ID P20138
Links - -
Type protein
Relations 3
Function Putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Induces apoptosis in acute myeloid leukemia (in vitro).

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation CD33 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding CD33
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding CD33
Publications: 1 Organism: Homo Sapiens