Summary

Name CD33
Full Name Myeloid cell surface antigen CD33
Synonyms Sialic acid-binding Ig-like lectin 3, Siglec-3, gp67 | SIGLEC3
Primary ID P20138
Links - -
Type protein
Relations 3
Function Sialic-acid-binding immunoglobulin-like lectin (Siglec) that plays a role in mediating cell-cell interactions and in maintaining immune cells in a resting state (PubMed:10611343, PubMed:15597323, PubMed:11320212). Preferentially recognizes and binds alpha-2,3- and more avidly alpha-2,6-linked sialic acid-bearing glycans (PubMed:7718872). Upon engagement of ligands such as C1q or syalylated glycoproteins, two immunoreceptor tyrosine-based inhibitory motifs (ITIMs) located in CD33 cytoplasmic tail are phosphorylated by Src-like kinases such as LCK (PubMed:28325905, PubMed:10887109). These phosphorylations provide docking sites for the recruitment and activation of protein-tyrosine phosphatases PTPN6/SHP-1 and PTPN11/SHP-2 (PubMed:10556798, PubMed:10206955, PubMed:10887109). In turn, these phosphatases regulate downstream pathways through dephosphorylation of signaling molecules (PubMed:10206955, PubMed:10887109). One of the repressive effect of CD33 on monocyte activation requires phosphoinositide 3-kinase/PI3K (PubMed:15597323).

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation CD33 0.273
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding CD33 0.4
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding CD33 0.4
Publications: 1 Organism: Homo Sapiens