3.0
Summary
| Name |  CD33View Modifications |
| Full Name | Myeloid cell surface antigen CD33 |
| Synonyms | Sialic acid-binding Ig-like lectin 3, Siglec-3, gp67 | SIGLEC3 |
| Primary ID | P20138 |
| Links |  -  -  |
| Type | protein |
| Relations | 3 |
| Function | Sialic-acid-binding immunoglobulin-like lectin (Siglec) that plays a role in mediating cell-cell interactions and in maintaining immune cells in a resting state (PubMed:10611343, PubMed:15597323, PubMed:11320212). Preferentially recognizes and binds alpha-2,3- and more avidly alpha-2,6-linked sialic acid-bearing glycans (PubMed:7718872). Upon engagement of ligands such as C1q or syalylated glycoproteins, two immunoreceptor tyrosine-based inhibitory motifs (ITIMs) located in CD33 cytoplasmic tail are phosphorylated by Src-like kinases such as LCK (PubMed:28325905, PubMed:10887109). These phosphorylations provide docking sites for the recruitment and activation of protein-tyrosine phosphatases PTPN6/SHP-1 and PTPN11/SHP-2 (PubMed:10556798, PubMed:10206955, PubMed:10887109). In turn, these phosphatases regulate downstream pathways through dephosphorylation of signaling molecules (PubMed:10206955, PubMed:10887109). One of the repressive effect of CD33 on monocyte activation requires phosphoinositide 3-kinase/PI3K (PubMed:15597323). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | LCK | up-regulates 
phosphorylation
|
CD33 | 0.275 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | gemtuzumab ozogamicin | down-regulates activity 
binding
|
CD33 | 0.4 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | blinatumomab | down-regulates activity
binding
|
CD33 | 0.4 |
| Publications: | 1 | Organism: | Homo Sapiens | |