+ |
MAK | up-regulates activity
phosphorylation
|
MAK |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-260779 |
Thr157 |
LRSQPPYtDYVSTRW |
Homo sapiens |
|
pmid |
sentence |
21986944 |
We conclude that dual phosphorylation on the TDY motif is crucial for MAK activity, and that the autokinase activity is required for this phosphorylation |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-260780 |
Tyr159 |
SQPPYTDyVSTRWYR |
Homo sapiens |
|
pmid |
sentence |
21986944 |
We conclude that dual phosphorylation on the TDY motif is crucial for MAK activity, and that the autokinase activity is required for this phosphorylation |
|
Publications: |
2 |
Organism: |
Homo Sapiens |
+ |
MAK | down-regulates
phosphorylation
|
CDH1 |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-278486 |
|
|
Homo sapiens |
|
pmid |
sentence |
21986944 |
Finally, we speculate that there are two mechanisms whereby MAK inactivates CDH1 : the first is kinase dependent inactivation, modeled after CDK, where phosphorylation dissociates CDH1 from APC/C; the second is through physical binding of CDH1 with MAK.|These results suggest a cell cycle-dependent phosphorylation of CDH1 by MAK. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |