Summary

Name CDH1
Full Name Cadherin-1
Synonyms CAM 120/80, Epithelial cadherin, E-cadherin, Uvomorulin | CDHE, UVO
Primary ID P12830
Links - -
Type protein
Relations 67
Pathways Hippo Signaling
Function Cadherins are calcium-dependent cell adhesion proteins (PubMed:11976333). They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells (PubMed:11976333). Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7.

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination CDH1 0.268
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation CDH1 0.298
Publications: 2
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation CDH1 0.412
Publications: 2
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation CDH1 0.432
Publications: 2
+ up-regulates activity img/direct-activation.png phosphorylation CDH1 0.402
Publications: 3 Organism: Mus Musculus
+ down-regulates activity img/direct_inhibition.png phosphorylation CDH1 0.26
Publications: 1
Pathways:Hippo Signaling
+ down-regulates activity img/direct_inhibition.png phosphorylation CDH1 0.313
Publications: 1
+ down-regulates activity img/direct_inhibition.png phosphorylation CDH1 0.27
Publications: 1
Pathways:Hippo Signaling
+ up-regulates activity img/direct-activation.png phosphorylation CDH1 0.562
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png phosphorylation CDH1 0.2
Publications: 1 Organism: Cricetulus Griseus
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation CDH1 0.755
Publications: 3 Organism: Homo Sapiens,
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation CDH1 0.312
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation CDH1 0.599
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity img/direct-activation.png relocalization CDH1 0.565
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation CDH1 0.68
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation CDH1 0.488
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation CDH1 0.493
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding APC-c 0.388
Publications: 1
+ up-regulates img/indirect-activation.png CDH1 0.7
Publications: 1 Organism: Homo Sapiens
Pathways:Hippo Signaling
+ up-regulates quantity by stabilization img/direct-activation.png binding CDH1 0.947
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CDH1 0.387
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation CDH1 0.414
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png dephosphorylation CDH1 0.314
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation CDH1 0.268
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding α-Catenin 0.684
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding CDH1 0.325
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation CDH1 0.258
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CDH1 0.454
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png cleavage CDH1 0.546
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation CDH1 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation CDH1 0.306
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png Epithelial-mesenchymal_transition 0.7
Publications: 1
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation CDH1 0.685
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding CTNNB1 0.96
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation CDH1 0.289
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation CDH1 0.385
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png binding CDH1 0.424
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation CDH1 0.2
Publications: 1 Organism: Mus Musculus
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation CDH1 0.445
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png post transcriptional regulation CDH1 0.4
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png chemical activation CDH1 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination CDH1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png post transcriptional regulation CDH1 0.4
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation CDH1 0.303
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CDH1 0.283
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding CTNNA1 0.684
Publications: 1 Organism: Homo Sapiens
Pathways:Hippo Signaling
+ up-regulates quantity by expression img/direct-activation.png post transcriptional regulation CDH1 0.4
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation CDH1 0.493
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation CDH1 0.759
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CDH1 0.324
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png deubiquitination CDH1 0.2
Publications: 1
+ down-regulates quantity by destabilization img/direct_inhibition.png binding FBXO31 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation CDH1 0.346
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation CDH1 0.417
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding AE/b7 integrin 0.651
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination CDH1 0.29
Publications: 1
Pathways:Hippo Signaling
+ up-regulates quantity img/direct-activation.png relocalization CDH1 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity img/indirect_inhibition.png transcriptional regulation CDH1 0.759
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png binding CDH1 0.449
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding LRP6 0.366
Publications: 1 Organism: Homo Sapiens