| + |
CAPN3 | up-regulates activity 
cleavage
|
GSK3B |
0.275 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251607 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25969760 |
Thus, it has been shown that calpain cleaves the inhibitory domain of GSK3 generating two fragments of 40 and 30 kDa. This cleavage enhanced activity of the kinase |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CAPN3 | up-regulates activity
cleavage
|
CDK5/CDK5R1 |
0.33 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251602 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25969760 |
Calpains also modulate the activity of CDK5. Physiologically, CDK 5 is activated by p35 and its cleaved product p25. The latter has a longer half life than p35 and therefore it is a more potent activator of CDK5. The cleavage of p35 to p25 is mediated by calpain |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CAPN3 | up-regulates activity
cleavage
|
GSK3A |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251606 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25969760 |
Thus, it has been shown that calpain cleaves the inhibitory domain of GSK3 generating two fragments of 40 and 30 kDa. This cleavage enhanced activity of the kinase |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CAPN3 | down-regulates activity 
cleavage
|
MAPT |
0.331 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251605 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25969760 |
Besides tau phosphorylation, calpain activation might play a role in tau-mediated neurodegeneration by inducing tau cleavage. In vitro studies have shown that both fetal and adult tau isoforms are rapidly proteolyzed by calpains |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CAST | down-regulates activity
binding
|
CAPN3 |
0.588 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251603 |
|
|
Homo sapiens |
Alzheimer Disease Specific Cell Type |
| pmid |
sentence |
| 25969760 |
In addition to Ca2+, calpastatin has a key role in the regulation of calpain. Calpastatin, a heat-stable protein ranging from ~70 to ~140 kDa of apparent molecular weight depending on the cell type, is considered a specific endogenous inhibitor of calpains|The calpastatin molecule contains four inhibitory units [75–77]. Each of these units binds to one calpain molecule [75–77]. Therefore, the ratio calpain/calpastatin plays a key role in the regulation of calpain activity [78–80]. The inhibitory effect of calpastatin requires Ca2+-dependent high-affinity binding to three sites of calpain |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CAPN3 | up-regulates activity
cleavage
|
CDK5R1 |
0.265 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251604 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25969760 |
Calpains also modulate the activity of CDK5. Physiologically, CDK 5 is activated by p35 and its cleaved product p25. The latter has a longer half life than p35 and therefore it is a more potent activator of CDK5. The cleavage of p35 to p25 is mediated by calpain |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
CAPN3
- 
- 