Summary

Name IL11
Full Name Interleukin-11
Synonyms IL-11, Adipogenesis inhibitory factor, AGIF
Primary ID P20809
Links - -
Type protein
Relations 4
Pathways iCAF signaling in PDAC
Function Cytokine that stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production (PubMed:2145578). Also promotes the proliferation of hepatocytes in response to liver damage. Binding to its receptor formed by IL6ST and IL11RA activates a signaling cascade that promotes cell proliferation (PubMed:12919066). Signaling leads to the activation of intracellular protein kinases and the phosphorylation of STAT3. The interaction with the membrane-bound IL11RA and IL6ST stimulates 'classic signaling', whereas the binding of IL11 and soluble IL11RA to IL6ST stimulates 'trans-signaling' (PubMed:30279168).

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Relations

Regulator Mechanism target score ℹ
+ IL11up-regulates activity img/direct-activation.png binding IL6ST 0.713
Publications: 1 Organism: Homo Sapiens
+ IL11up-regulates img/direct-activation.png binding IL11RA 0.736
Publications: 1 Organism: Homo Sapiens
+ IL11up-regulates img/direct-activation.png binding IL6ST 0.713
Publications: 1 Organism: Homo Sapiens
+ Activated PSCup-regulates img/direct-activation.png IL11 0.7
Publications: 1 Organism: Homo Sapiens