3.0
Summary
| Name |  IL11
|
| Full Name | Interleukin-11 |
| Synonyms | IL-11, Adipogenesis inhibitory factor, AGIF |
| Primary ID | P20809 |
| Links |  -  -  |
| Type | protein |
| Relations | 3 |
| Pathways | iCAF signaling in PDAC |
| Function | Cytokine that stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production (PubMed:2145578). Also promotes the proliferation of hepatocytes in response to liver damage. Binding to its receptor formed by IL6ST and IL11RA activates a signaling cascade that promotes cell proliferation (PubMed:12919066). Signaling leads to the activation of intracellular protein kinases and the phosphorylation of STAT3. The interaction with the membrane-bound IL11RA and IL6ST stimulates 'classic signaling', whereas the binding of IL11 and soluble IL11RA to IL6ST stimulates 'trans-signaling' (PubMed:30279168). |
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