Summary

Name IL6ST
Full Name Interleukin-6 receptor subunit beta
Synonyms IL-6 receptor subunit beta, IL-6R subunit beta, IL-6R-beta, IL-6RB, CDw130, Interleukin-6 signal transducer, Membrane glycoprotein 130, gp130, Oncostatin-M receptor subunit alpha
Primary ID P40189
Links - -
Type protein
Relations 24
Pathways IL6 Signaling, Macrophage: IL6, Macrophage: Polarization and myogenesis, Multiple sclerosis, Myoblast: IL6 and hypertrophy, Myofiber: IL6 and atrophy, SARS-CoV CYTOKINE STORM, Satellite: IL6, T-Lymphocyte: IL6
Function Signal-transducing molecule (PubMed:2261637). The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize IL6ST for initiating signal transmission. Binding of IL6 to IL6R induces IL6ST homodimerization and formation of a high-affinity receptor complex, which activate the intracellular JAK-MAPK and JAK-STAT3 signaling pathways (PubMed:2261637, PubMed:19915009, PubMed:23294003). That causes phosphorylation of IL6ST tyrosine residues which in turn activates STAT3 (PubMed:19915009, PubMed:23294003, PubMed:25731159). In parallel, the IL6 signaling pathway induces the expression of two cytokine receptor signaling inhibitors, SOCS1 and SOCS3, which inhibit JAK and terminate the activity of the IL6 signaling pathway as a negative feedback loop (By similarity). Also activates the yes-associated protein 1 (YAP) and NOTCH pathways to control inflammation-induced epithelial regeneration, independently of STAT3 (By similarity). Mediates signals which regulate immune response, hematopoiesis, pain control and bone metabolism (By similarity). Has a role in embryonic development (By similarity). Essential for survival of motor and sensory neurons and for differentiation of astrocytes (By similarity). Required for expression of TRPA1 in nociceptive neurons (By similarity). Required for the maintenance of PTH1R expression in the osteoblast lineage and for the stimulation of PTH-induced osteoblast differentiation (By similarity). Required for normal trabecular bone mass and cortical bone composition (By similarity).

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png phosphorylation IL6ST 0.2
Publications: 2 Organism: In Vitro
Pathways:IL6 Signaling, Multiple sclerosis, SARS-CoV CYTOKINE STORM
+ up-regulates img/direct-activation.png phosphorylation IL6ST 0.339
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation IL6ST 0.339
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation JAK2 0.621
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding IL6ST 0.738
Publications: 1 Organism: Homo Sapiens
Pathways:IL6 Signaling
+ up-regulates img/direct-activation.png binding IL6ST 0.736
Publications: 2 Organism: Homo Sapiens
Pathways:IL6 Signaling, Multiple sclerosis, SARS-CoV CYTOKINE STORM
+ up-regulates img/direct-activation.png binding IL6ST 0.539
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding SHC1 0.352
Publications: 1 Organism: Homo Sapiens
Pathways:IL6 Signaling
+ up-regulates img/direct-activation.png binding IL6ST 0.702
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding IL6ST 0.608
Publications: 1 Organism: Homo Sapiens
Pathways:IL6 Signaling
+ up-regulates img/indirect-activation.png ERK1/2 0.284
Publications: 1 Organism: Homo Sapiens
Pathways:IL6 Signaling
+ down-regulates activity img/direct_inhibition.png binding IL6ST 0.634
Publications: 2 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle
Pathways:IL6 Signaling
+ up-regulates img/direct-activation.png binding IL6ST 0.583
Publications: 1 Organism: Homo Sapiens
Pathways:IL6 Signaling
+ up-regulates img/direct-activation.png binding IL6ST 0.778
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png T_cell_activation 0.7
Publications: 1 Organism: Homo Sapiens
Pathways:Multiple sclerosis, SARS-CoV CYTOKINE STORM
+ up-regulates img/direct-activation.png , binding JAK1 0.66
Publications: 2 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle
Pathways:IL6 Signaling, Multiple sclerosis, SARS-CoV CYTOKINE STORM
+ up-regulates activity img/indirect-activation.png IL6ST 0.863
Publications: 1 Organism: In Vitro
Pathways:IL6 Signaling, Multiple sclerosis, SARS-CoV CYTOKINE STORM
+ up-regulates activity img/direct-activation.png binding IL6ST 0.863
Publications: 1 Organism: Homo Sapiens
Pathways:IL6 Signaling, Multiple sclerosis, SARS-CoV CYTOKINE STORM
+ up-regulates img/direct-activation.png binding IL6ST 0.667
Publications: 1 Organism: Homo Sapiens