| + |
IL6ST | up-regulates activity 
phosphorylation
|
IL6ST |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-238621 |
Ser659 |
WPNVPDPsKSHIAQW |
in vitro |
|
| pmid |
sentence |
| 8511589 |
The biological functions of interleukin-6 (IL-6) are mediated through a signal-transducing component of the IL-6 receptor, gp130, which is associated with the ligand-occupied IL-6 receptor (IL-6R) protein. Binding of IL-6 to IL-6R induced disulfide-linked homodimerization of gp130. Tyrosine kinase activity was associated with dimerized but not monomeric gp130 protein. Substitution of serine for proline residues 656 and 658 in the cytoplasmic motif abolished tyrosine kinase activation and cellular responses but not homodimerization of gp130. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-238625 |
Ser661 |
NVPDPSKsHIAQWSP |
in vitro |
|
| pmid |
sentence |
| 8511589 |
The biological functions of interleukin-6 (IL-6) are mediated through a signal-transducing component of the IL-6 receptor, gp130, which is associated with the ligand-occupied IL-6 receptor (IL-6R) protein. Binding of IL-6 to IL-6R induced disulfide-linked homodimerization of gp130. Tyrosine kinase activity was associated with dimerized but not monomeric gp130 protein. Substitution of serine for proline residues 656 and 658 in the cytoplasmic motif abolished tyrosine kinase activation and cellular responses but not homodimerization of gp130. |
|
| Publications: |
2 |
Organism: |
In Vitro |
| Pathways: | IL6 Signaling, Multiple sclerosis, SARS-CoV CYTOKINE STORM |
| + |
PRKCD | up-regulates
phosphorylation
|
IL6ST |
0.339 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-94012 |
Thr890 |
GQVERFEtVGMEAAT |
Homo sapiens |
|
| pmid |
sentence |
| 12361954 |
This interaction, which does not seem to involve a classical phosphotyrosine sh2-mediated binding, however, significantly enhances the interaction of stat3 and the il-6 receptor subunit glycoprotein (gp) 130, which is the initial step for stat3 activation by il-6. Expression of a dominant negative pkcdelta or depletion of the endogenous pkcdelta by phorbol 12-myristate 3-acetate treatment abrogates the association of stat3 with gp130. At the same time, pkcdelta is recruited to gp130 via association with stat3, which may facilitate its phosphorylation on the gp130 receptor. Finally, we identified thr-890, a putative pkc phosphorylation site on gp130, to be critical for the effect of pkcdelta. Our data indicate that pkcdelta plays important regulatory roles in il-6 signaling. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PRKCD | up-regulates activity
phosphorylation
|
IL6ST |
0.339 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249177 |
Thr909 |
PKSYLPQtVRQGGYM |
in vitro |
|
| pmid |
sentence |
| 12361954 |
Finally, we identified Thr-890, a putative PKC phosphorylation site on gp130, to be critical for the effect of PKCdelta. Our data indicate that PKCdelta plays important regulatory roles in IL-6 signaling. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
IL6ST | up-regulates activity
phosphorylation
|
JAK2 |
0.624 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-238630 |
Tyr1007 |
VLPQDKEyYKVKEPG |
Homo sapiens |
|
| pmid |
sentence |
| 9716487 |
All IL-6-type cytokines recruit gp130to their receptot complexes They either signal via gp130 alone [8] or in combination with LIFR [9] or the recently cloned OSMR [10], which are all able to activate Jaks proteins. Two tyrosine residues at the corresponding positions of Jak2 (tyrosine-1007 and tyrosine-1008) were found to be phosphorylated, and a single mutation of tyrosine-1007 eliminated essentially all tyrosine kinase activity [59]. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-238634 |
Tyr1008 |
LPQDKEYyKVKEPGE |
Homo sapiens |
|
| pmid |
sentence |
| 9716487 |
All IL-6-type cytokines recruit gp130to their receptot complexes They either signal via gp130 alone [8] or in combination with LIFR [9] or the recently cloned OSMR [10], which are all able to activate Jaks proteins. Two tyrosine residues at the corresponding positions of Jak2 (tyrosine-1007 and tyrosine-1008) were found to be phosphorylated, and a single mutation of tyrosine-1007 eliminated essentially all tyrosine kinase activity [59]. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
LIFR | up-regulates
binding
|
IL6ST |
0.587 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-204850 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24710148 |
The binding of lif to the lifr induces its heterodimerization with gp130. The formation of this complex results in the activation of the receptor-associated janus kinases (jaks), in the phosphorylation of receptor docking sites, and finally in the recruitment of src homology-2 (sh2) domain containing proteins such as stat3 (signal transducer and activator of transcription 3). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | IL6 Signaling |
| + |
IL6ST | up-regulates
, binding
|
JAK1 |
0.662 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-202036 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23663276 |
Il-6 family members typically signal through the common gp130 receptor, with the janus kinase/signal transducer and activator of transcription (jak/stat) pathway being the major intracellular mediator of their effects. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-204841 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24710148 |
The binding of lif to the lifr induces its heterodimerization with gp130. The formation of this complex results in the activation of the receptor-associated janus kinases (jaks), in the phosphorylation of receptor docking sites, and finally in the recruitment of src homology-2 (sh2) domain containing proteins such as stat3 (signal transducer and activator of transcription 3). |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Tissue: |
Muscle, Skeletal Muscle |
| Pathways: | IL6 Signaling, Multiple sclerosis, SARS-CoV CYTOKINE STORM |
| + |
IL6ST | up-regulates
binding
|
SHC1 |
0.352 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250574 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9126968 |
Shc mediates IL-6 signaling by interacting with gp130 and Jak2 kinase. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | IL6 Signaling |
| + |
IL6R | up-regulates
binding
|
IL6ST |
0.74 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-202033 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23663276 |
In classical il-6 signaling, the cytokine first binds to the membrane-bound il-6 receptor (il-6r;cd126) that is induced to associate with a homodimer of gp130 which then transmits the intracellular signal. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-105504 |
|
|
Homo sapiens |
Lymphoma Cell |
| pmid |
sentence |
| 11238858 |
Part of the receptor for interleukin 6. Binds to il6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with il6st. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | IL6 Signaling, Multiple sclerosis, SARS-CoV CYTOKINE STORM |
| + |
IL6ST | up-regulates 
|
T_cell_activation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261028 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 32234467 |
Interleukin-6 (IL-6) is an important member of the cytokine network and plays a central role in acute inflammation. IL-6 binds to its receptor IL-6R to form a complex, and then binds to the membrane protein gp130 to initiate intracellular signal transduction. IL-6 is the terminal helper factor of cytotoxic T lymphocyte (CTL), which can induce CTL activity and make immature thymocytes develop into CTL. In addition, IL-6 is a pro-inflammatory regulator of T cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Multiple sclerosis, SARS-CoV CYTOKINE STORM |
| + |
IL6 | up-regulates activity
binding
|
IL6ST |
0.864 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-48041 |
|
|
Homo sapiens |
Leukemia Cell |
| pmid |
sentence |
| 15895091 |
A crystal structure of the ligand-binding domains of gp130 in complex with human interleukin-6 (il-6) and its a-receptor (il-6ralpha) revealed a hexameric architecture in which the gp130 membrane-distal regions were approximately 100 a apart, in contrast to the close apposition seen between short cytokine receptor complexes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | IL6 Signaling, Multiple sclerosis, SARS-CoV CYTOKINE STORM |
| + |
IL11 | up-regulates
binding
|
IL6ST |
0.703 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-48033 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9143707 |
Some of these biological activities of il-6 are also often exerted by other cytokines, i.e. Il-11, lif, osm, cntf, and ct-4 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IL6 | up-regulates activity
|
IL6ST |
0.864 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-238617 |
|
|
in vitro |
|
| pmid |
sentence |
| 8511589 |
The biological functions of interleukin-6 (IL-6) are mediated through a signal-transducing component of the IL-6 receptor, gp130, which is associated with the ligand-occupied IL-6 receptor (IL-6R) protein. Binding of IL-6 to IL-6R induced disulfide-linked homodimerization of gp130. Tyrosine kinase activity was associated with dimerized but not monomeric gp130 protein. Substitution of serine for proline residues 656 and 658 in the cytoplasmic motif abolished tyrosine kinase activation and cellular responses but not homodimerization of gp130. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| Pathways: | IL6 Signaling, Multiple sclerosis, SARS-CoV CYTOKINE STORM |
| + |
SOCS3 | down-regulates activity 
binding
|
IL6ST |
0.637 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-202045 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19620279 |
We now show that SOCS1, SOCS3, and PIAS1 promote myogenic differentiation by specifically inhibiting the LIF-induced JAK1/STAT1/STAT3 pathway via distinct targets; whereas SOCS1 and SOCS3 selectively bind and inhibit JAK1 and gp130, respectively, PIAS1 targets mainly the activated STAT1 and prevents its binding to DNA. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255328 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23454976 |
SOCS3 binds specific receptor-JAK complexes to control cytokine signaling by direct kinase inhibition. The inhibitory protein SOCS3 plays a key part in the immune and hematopoietic systems by regulating signaling induced by specific cytokines. SOCS3 functions by inhibiting the catalytic activity of Janus kinases (JAKs) that initiate signaling within the cell. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Tissue: |
Muscle, Skeletal Muscle |
| Pathways: | IL6 Signaling |
| + |
LIF | up-regulates
binding
|
IL6ST |
0.781 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-48108 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9143707 |
Stimulation of cells with the interleukin-6 family of cytokines triggers homo- or hetero-dimerization of gp130. The dimerization of gp130 leads to activation of associated cytoplasmic tyrosine kinases and subsequent modification of transcription factors.Some Of these biological activities of il-6 are also often exerted by other cytokines, i.e. Il-11, lif, osm, cntf, and ct-2 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CNTF | up-regulates
binding
|
IL6ST |
0.669 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-47991 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9143707 |
Stimulation of cells with the interleukin-6 family of cytokines triggers homo- or hetero-dimerization of gp130. The dimerization of gp130 leads to activation of associated cytoplasmic tyrosine kinases and subsequent modification of transcription factors. Some of these biological activities of il-6 are also often exerted by other cytokines, i.e. Il-11, lif, osm, cntf, and ct-2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
OSM | up-regulates
binding
|
IL6ST |
0.741 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-48114 |
|
|
Homo sapiens |
Leukemia Cell |
| pmid |
sentence |
| 9143707 |
Stimulation of cells with the interleukin-6 family of cytokines triggers homo- or hetero-dimerization of gp130. The dimerization of gp130 leads to activation of associated cytoplasmic tyrosine kinases and subsequent modification of transcription factors. Some of these biological activities of il-6 are also often exerted by other cytokines, i.e. Il-11, lif, osm, cntf, and ct-2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | IL6 Signaling |
| + |
IL11 | up-regulates activity
binding
|
IL6ST |
0.703 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277689 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 28232471 |
Because GP130 is known to interact with other ligand-receptor pairs, we measured the expression of additional GP130 signaling partners in both organoids and PSCs in trans-well cultures. Of the GP130 ligands found to be expressed in PSCs, Il6, Il11, and leukemia inhibitory factor (Lif) were the most highly up-regulated in trans-well cultures when compared with PSC monocultures (Fig. 3 C). Both IL-11 and LIF are reported to have roles in cancer progression |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IL6ST | up-regulates
|
ERK1/2 |
0.282 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255022 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16306329 |
Upon formation of the IL-6/IL-6Ralpha/gp130 hexameric signaling complex, two distinct signaling pathways are activated: 1) Janus kinase (JAK)/signal transducers and activator of transcription (STAT) and 2) the Src homology 2-containing tyrosine phosphatase (SHP-2)/extracellular signal-regulated kinase (ERK)/mitogen-activated protein kinase (MAPK) pathways |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | IL6 Signaling |
| + |
CLCF1 | up-regulates
binding
|
IL6ST |
0.542 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-47959 |
|
|
Homo sapiens |
Leukemia Cell |
| pmid |
sentence |
| 9143707 |
Some of these biological activities of il-6 are also often exerted by other cytokines, i.e. Il-11, lif, osm, cntf, and ct-6 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CTF1 | up-regulates
binding
|
IL6ST |
0.611 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-46509 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9030543 |
In the cos-7 cell line demonstrate that gp130-gp190 heterocomplex formation is essential for ct-1 signaling |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | IL6 Signaling |
3.0
IL6ST
- 
- 