+ |
IMPDH1 | down-regulates quantity
chemical modification
|
IMP |
0.8 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-267331 |
|
|
Homo sapiens |
|
pmid |
sentence |
19480389 |
IMPDH controls the gateway to guanine nucleotides, making it an “enzyme of consequence” for virtually every organism. The IMPDH-catalyzed conversion of IMP to XMP is the first committed and rate-limiting step in guanine nucleotide biosynthesis. XMP is subsequently converted to GMP by the action of GMP synthetase (GMPS). |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
Pathways: | Nucleotide Biosynthesis |
+ |
IMPDH1 | up-regulates quantity
chemical modification
|
5'-xanthylic acid |
0.8 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-267332 |
|
|
Homo sapiens |
|
pmid |
sentence |
19480389 |
IMPDH controls the gateway to guanine nucleotides, making it an “enzyme of consequence” for virtually every organism. The IMPDH-catalyzed conversion of IMP to XMP is the first committed and rate-limiting step in guanine nucleotide biosynthesis. XMP is subsequently converted to GMP by the action of GMP synthetase (GMPS). |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
Pathways: | Nucleotide Biosynthesis |
+ |
MYC | up-regulates quantity by expression
transcriptional regulation
|
IMPDH1 |
0.245 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-267378 |
|
|
Homo sapiens |
P493-6 Cell |
pmid |
sentence |
18628958 |
Here, we report that the majority of genes in human purine and pyrimidine biosynthesis pathway were induced and directly bound by c-Myc in the P493-6 human Burkitt's lymphoma model cell line. The mRNA levels of IMPDH1 and IMPDH2, the rate-limiting enzyme in purine de novo synthesis, increased with MYC induction both in vitro and in vivo. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
Pathways: | Nucleotide Biosynthesis |