Summary

Name SYT1
Full Name Synaptotagmin-1
Synonyms Synaptotagmin I, SytI, p65 | SVP65, SYT
Primary ID P21579
Links - -
Type protein
Relations 5
Pathways Neurotransmitters release
Function Calcium sensor that participates in triggering neurotransmitter release at the synapse (By similarity). May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse (By similarity). It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2. Plays a role in dendrite formation by melanocytes (PubMed:23999003).

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Relations

Regulator Mechanism target score ℹ
+ SV2Aup-regulates quantity img/direct-activation.png binding SYT1 0.536
Publications: 1 Organism: Homo Sapiens
Pathways:Neurotransmitters release
+ SYT1up-regulates activity img/direct-activation.png binding SNAP25 0.95
Publications: 1 Organism: Homo Sapiens
Pathways:Neurotransmitters release
+ calcium(2+)up-regulates activity img/direct-activation.png chemical activation SYT1 0.8
Publications: 1 Organism: Homo Sapiens
Pathways:Neurotransmitters release
+ STON2up-regulates quantity img/direct-activation.png binding SYT1 0.78
Publications: 1 Organism: Homo Sapiens
Pathways:Neurotransmitters release
+ SNAP91up-regulates quantity img/direct-activation.png binding SYT1 0.635
Publications: 1 Organism: Homo Sapiens