Summary

Name VDAC1
Full Name Voltage-dependent anion-selective channel protein 1
Synonyms VDAC-1, hVDAC1, Outer mitochondrial membrane protein porin 1, Plasmalemmal porin, Porin 31HL, Porin 31HM | VDAC
Primary ID P21796
Links - -
Type protein
Relations 7
Function Forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective (PubMed:11845315, PubMed:18755977, PubMed:20230784, PubMed:8420959). Binds various signaling molecules, including the sphingolipid ceramide, the phospholipid phosphatidylcholine, and the sterol cholesterol (PubMed:31015432). In depolarized mitochondria, acts downstream of PRKN and PINK1 to promote mitophagy or prevent apoptosis; polyubiquitination by PRKN promotes mitophagy, while monoubiquitination by PRKN decreases mitochondrial calcium influx which ultimately inhibits apoptosis (PubMed:32047033). May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis (PubMed:15033708, PubMed:25296756). May mediate ATP export from cells (PubMed:30061676).

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▶Modifications Tables

Relations

Regulator Mechanism target score ℹ
+ NEK1down-regulates img/direct_inhibition.png phosphorylation VDAC1 0.436
Publications: 1 Organism: Homo Sapiens
+ BCL2L1down-regulates activity img/direct_inhibition.png binding VDAC1 0.584
Publications: 1
+ BAXup-regulates activity img/direct-activation.png binding VDAC1 0.574
Publications: 1
+ SOD1down-regulates activity img/direct_inhibition.png binding VDAC1 0.437
Publications: 1 Organism: Mus Musculus
Tissue: Spinal Cord
+ FAM162Aup-regulates activity img/direct-activation.png binding VDAC1 0.2
Publications: 1 Organism: Homo Sapiens
+ TSPO2up-regulates activity img/direct-activation.png binding VDAC1 0.315
Publications: 1 Organism: Homo Sapiens
+ VDAC1up-regulates img/indirect-activation.png Apoptosis 0.7
Publications: 1