Relation Results

Summary

Name NEK1
Full Name Serine/threonine-protein kinase Nek1
Synonyms Never in mitosis A-related kinase 1, NimA-related protein kinase 1, Renal carcinoma antigen NY-REN-55 | KIAA1901
Primary ID Q96PY6
Links - -
Type protein
Relations 6
Function Phosphorylates serines and threonines, but also appears to possess tyrosine kinase activity (PubMed:20230784). Involved in DNA damage checkpoint contr ...
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Type: Score: Layout: SPV 
0.2580.4290.20.2920.2840.2NEK1VHLVDAC1ME1TLK1ATRIPATR

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ NEK1down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation VHL 0.258
Identifier Residue Sequence Organism Cell Line
SIGNOR-276434 Ser168 RCLQVVRsLVKPENY Homo sapiens HEK-293 Cell
pmid sentence
Nek1 phosphorylates Von Hippel-Lindau tumor suppressor to promote its proteasomal degradation and ciliary destabilization. Mutation of pVHL at S-168 increases protein stability.
Publications: 1 Organism: Homo Sapiens
+ NEK1down-regulates img/direct_inhibition.png phosphorylation VDAC1 0.429
Identifier Residue Sequence Organism Cell Line
SIGNOR-164222 Ser193 DGTEFGGsIYQKVNK Homo sapiens
pmid sentence
Nek1 phosphorylates vdac1 on ser193. Wild-type vdac1 assumes an open configuration, but closes and prevents cytochrome c efflux when phosphorylated by nek1. A vdac1-ser193ala mutant, which cannot be phosphorylated by nek1 under identical conditions, remains open and constitutively allows cytochrome c efflux.
Publications: 1 Organism: Homo Sapiens
+ NEK1down-regulates activity img/direct_inhibition.png phosphorylation ME1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-275570 Ser336 KKIWLVDsKGLIVKG
pmid sentence
PGAM5-mediated dephosphorylation of malic enzyme 1 (ME1) at S336 allows increased ACAT1-mediated K337 acetylation, leading to ME1 dimerization and activation, both of which are reversed by NEK1 kinase-mediated S336 phosphorylation. SIRT6 deacetylase antagonizes ACAT1 function in a manner that involves mutually exclusive ME1 S336 phosphorylation and K337 acetylation.
Publications: 1
+ TLK1up-regulates activity img/direct-activation.png phosphorylation NEK1 0.292
Identifier Residue Sequence Organism Cell Line
SIGNOR-275840 Thr141 IFLTKDGtVQLGDFG
pmid sentence
TLK1 phosphorylated NEK1 at T141, which lies in the kinase domain, and caused an increase in its activity. 
Publications: 1
+ NEK1up-regulates activity img/direct-activation.png binding ATRIP 0.284
Identifier Residue Sequence Organism Cell Line
SIGNOR-275842
pmid sentence
It was reported that NEK1 associates with ATR/ATRIP and primes it for activation in response to a variety of genotoxic agents
Publications: 1
+ NEK1up-regulates activity img/direct-activation.png binding ATR 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-275841
pmid sentence
It was reported that NEK1 associates with ATR/ATRIP and primes it for activation in response to a variety of genotoxic agents
Publications: 1
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