3.0
Summary
| Name |  NEK1View Modifications |
| Full Name | Serine/threonine-protein kinase Nek1 |
| Synonyms | Never in mitosis A-related kinase 1, NimA-related protein kinase 1, Renal carcinoma antigen NY-REN-55 | KIAA1901 |
| Primary ID | Q96PY6 |
| Links |  -  -  |
| Type | protein |
| Relations | 6 |
| Function | Phosphorylates serines and threonines, but also appears to possess tyrosine kinase activity (PubMed:20230784). Involved in DNA damage checkpoint control and for proper DNA damage repair (PubMed:20230784). In response to injury that includes DNA damage, NEK1 phosphorylates VDAC1 to limit mitochondrial cell death (PubMed:20230784). May be implicated in the control of meiosis (By similarity). Involved in cilium assembly (PubMed:21211617). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | NEK1 | down-regulates quantity by destabilization 
phosphorylation
|
VHL | 0.26 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | NEK1 | down-regulates
phosphorylation
|
VDAC1 | 0.436 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | NEK1 | down-regulates activity
phosphorylation
|
ME1 | 0.2 |
| Publications: | 1 | |||
| + | TLK1 | up-regulates activity 
phosphorylation
|
NEK1 | 0.295 |
| Publications: | 1 | |||
| + | NEK1 | up-regulates activity
binding
|
ATRIP | 0.287 |
| Publications: | 1 | |||
| + | NEK1 | up-regulates activity
binding
|
ATR | 0.2 |
| Publications: | 1 | |||