| + |
SDHB | form complex 
binding
|
Mitochondrial respiratory chain complex II |
0.965 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262189 |
|
|
|
|
| pmid |
sentence |
| 30030361 |
Complex II (EC 1.3.5.1) or succinate dehydrogenase (quinone) is shared between the TCA cycle and the ETC and has no proton pumping activity. It is composed of four nDNA-encoded subunits. The two hydrophilic catalytic subunits are SDHA/SDH1 and SDHB/SDH2. Hydrophobic subunits SDHC/SDH3 and SDHD/SDH4 constitute the cII membrane anchor, containing a haem b group and two CoQ binding sites |
|
| Publications: |
1 |
| + |
iron-sulfur cluster | up-regulates activity 
chemical activation
|
SDHB |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262133 |
|
|
|
|
| pmid |
sentence |
| 26083061 |
Succinate dehydrogenase subunit B contains three Fe-S clusters |The enzymatic activity of both proteins depends on the presence of intact Fe-S clusters |
|
| Publications: |
1 |
| + |
SDHAF2 | up-regulates
binding
|
SDHB |
0.637 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-187239 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19628817 |
Sdh5 is required for sdh activity and stability / the sdh1-sdh5 interaction is likely to be functionally important because the sdh5_ mutant lacks sdh activity |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SDHB | form complex
binding
|
SDH |
0.965 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266272 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16143825 |
Mitochondrial succinate dehydrogenase (SDH) consists merely of four nuclearly encoded subunits. It participates in the electron transfer in the respiratory chain and in succinate catabolism in the Krebs cycle. The SDH enzyme, also known as respiratory chain complex II, faces the mitochondrial matrix and is bound to the inner membrane. Four nuclear genes encode the four subunits, SDHA (15 exons), SDHB (8 exons), SDHC (6 exons) and SDHD (4 exons), mapping on to chromosomes 5p15, 1p35-p36.1, 1q21 and 11q23, respectively. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Citric acid cycle |
3.0
SDHB
- 
- 